M
Michael J. Caulfield
Researcher at International AIDS Vaccine Initiative
Publications - 63
Citations - 5715
Michael J. Caulfield is an academic researcher from International AIDS Vaccine Initiative. The author has contributed to research in topics: Antigen & DNA vaccination. The author has an hindex of 32, co-authored 63 publications receiving 5483 citations. Previous affiliations of Michael J. Caulfield include Merck & Co. & United States Military Academy.
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Journal ArticleDOI
Varicella Zoster Virus–Specific Immune Responses to a Herpes Zoster Vaccine in Elderly Recipients With Major Depression and the Impact of Antidepressant Medications
Michael R. Irwin,Myron J. Levin,Mark L. Laudenslager,Richard G. Olmstead,Anne Lucko,Nancy Lang,Carmen Carrillo,Harold A. Stanley,Michael J. Caulfield,Adriana Weinberg,Ivan S. F. Chan,Jim Clair,Jeffrey G. Smith,Rocio D. Marchese,Heather M. Williams,Danielle J. Beck,Patricia T. McCook,Jane H. Zhang,Gary R. Johnson,Michael N. Oxman,Michael N. Oxman +20 more
TL;DR: Depressed patients have diminished VZV-CMI responses to zoster vaccine, and treatment with antidepressant medication is associated with normalization of these responses, and untreated depression may increase the risk and severity of HZ and reduce the efficacy of zoster vaccines.
Journal ArticleDOI
Major Depressive Disorder and Immunity to Varicella-Zoster Virus in the Elderly
Michael R. Irwin,Myron J. Levin,Carmen Carrillo,Richard G. Olmstead,Anne Lucko,Nancy Lang,Michael J. Caulfield,Adriana Weinberg,Ivan S. F. Chan,Jim Clair,Jeffrey G. Smith,Rocio D. Marchese,Heather M. Williams,Danielle J. Beck,Patricia T. McCook,Gary R. Johnson,Michael N. Oxman,Michael N. Oxman +17 more
TL;DR: Since lower levels of VZV-RCF appear to explain the increased risk and severity of herpes zoster observed in older adults, these findings suggest that, in addition to increasing age, depression may increase the risk and seriousness of herpesZoster.
Journal Article
DNA vaccines. Mechanisms for generation of immune responses.
Journal ArticleDOI
A simple and efficient method for the monitoring of antigen-specific T cell responses using peptide pool arrays in a modified ELISpot assay.
Timothy W Tobery,Su Wang,Xin-Min Wang,Michael P. Neeper,Kathrin U. Jansen,Mcclements William L,Michael J. Caulfield +6 more
TL;DR: Using arrays of pools of overlapping 20mer peptides, the use of peptide pool arrays allows for the identification of epitope-specific responses using far fewer cells than is required for testing a panel of overlapping peptides individually, making this strategy particularly useful in clinical settings where immune cells may be limiting.
Journal ArticleDOI
Safety, tolerability, and immunogenicity after 1 and 2 doses of zoster vaccine in healthy adults ≥60 years of age
Joost N. Vermeulen,Joep M. A. Lange,Stephen K. Tyring,Patrick H. Peters,Margaret Nunez,Gregory A. Poland,Myron J. Levin,Carrie Freeman,Ira Chalikonda,Jianjun Li,Jeffrey G. Smith,Michael J. Caulfield,Jon E. Stek,Ivan S. F. Chan,Rupert Vessey,Florian Schödel,Paula W. Annunziato,Katia Schlienger,Jeffrey L. Silber +18 more
TL;DR: A second dose of zoster vaccine was generally safe, but did not boost VZV-specific immunity beyond levels achieved postdose 1, and ZV was generally well-tolerated and immunogenic in adults ≥60 years old.