Yen Ying Lim

TL;DR: The reserve, resilience, and protective factors professional interest area established a whitepaper workgroup to develop consensus definitions for cognitive reserve, brain reserve, and brain maintenance and evaluated measures that have been used to implement these concepts in research settings and developed guidelines for research that explores or utilizes these concepts.

TL;DR: This work aimed to determine the prognostic value of β‐amyloid imaging, alone and in combination with memory performance, hippocampal atrophy, and apolipoprotein E ε4 status in nondemented, older individuals.

TL;DR: The large variance in cognitive deterioration in subjects who test positive for amyloid-β by positron emission tomography indicates that convergent pathologies, such as iron accumulation, might combine with amyloids-β to accelerate Alzheimer's disease progression.

TL;DR: The combined detection of amyloid positivity and objectively-defined decline in memory are reliable indicators of early Alzheimer's disease, and the detection of decline in non-memory functions in amyloids-positive individuals with mild cognitive impairment may assist in determining the level of disease severity in these individuals.

TL;DR: These results provide additional support for the deleterious effect of elevated Aβ levels on cognitive function in preclinical AD and suggest that elevated anxiety symptoms moderate the effect of Aβ on cognitive decline in pre clinical AD, resulting in more rapid decline in several cognitive domains.