Michael McGregor

TL;DR: A human–SARS-CoV-2 protein interaction map highlights cellular processes that are hijacked by the virus and that can be targeted by existing drugs, including inhibitors of mRNA translation and predicted regulators of the sigma receptors.

TL;DR: The identification of host dependency factors mediating virus infection may provide key insights into effective molecular targets for developing broadly acting antiviral therapeutics against SARS-CoV-2 and other deadly coronavirus strains.

TL;DR: In this paper , the authors proposed that genetic determinants for CHD may lie in the protein interactomes of transcription factors whose mutations cause CHDs, and defined the interactome of two transcription factors haplo-insufficient in CHD, GATA4 and TBX5 within human cardiac progenitors, and integrating the results with nearly 9,000 exomes from proband-parent trios revealed an enrichment of de novo missense variants associated with CHD within the interactomes.

TL;DR: In this paper , the authors target 426 genes previously implicated in the HIV lifecycle through protein interaction studies for CRISPR-Cas9-mediated knockout in primary human CD4+ T cells in order to systematically assess their functional roles in HIV replication.

TL;DR: Gonzalez-Teran, Barbara; Pittman, Maureen; Felix, Franco; Richmond-Buccola, Desmond; Thomas, Reuben; Choudhary, Krishna; Moroni, Elisabetta; Colombo, Giorgio; Alexanian, Michael; Gifford, Casey A; Huttenhain, Ruth; Gelb, Bruce D; Conklin, Bruce; Black, Brian L; Bruneau, Benoit G; Krogan, Nevan J; Pollard, Katherine S; Srivastava, Deep