P
Phillip P. Sharp
Researcher at University of California, San Francisco
Publications - 25
Citations - 4838
Phillip P. Sharp is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Bromodomain & BRD4. The author has an hindex of 15, co-authored 23 publications receiving 3236 citations. Previous affiliations of Phillip P. Sharp include University of Melbourne & Walter and Eliza Hall Institute of Medical Research.
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Journal ArticleDOI
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
David E. Gordon,Gwendolyn M. Jang,Mehdi Bouhaddou,Jiewei Xu,Kirsten Obernier,Kris M. White,Matthew J. O’Meara,Veronica V. Rezelj,Jeffrey Z. Guo,Danielle L. Swaney,Tia A. Tummino,Ruth Hüttenhain,Robyn M. Kaake,Alicia L. Richards,Beril Tutuncuoglu,Helene Foussard,Jyoti Batra,Kelsey M. Haas,Maya Modak,Minkyu Kim,Paige Haas,Benjamin J. Polacco,Hannes Braberg,Jacqueline M. Fabius,Manon Eckhardt,Margaret Soucheray,Melanie J. Bennett,Merve Cakir,Michael McGregor,Qiongyu Li,Bjoern Meyer,Ferdinand Roesch,Thomas Vallet,Alice Mac Kain,Lisa Miorin,Elena Moreno,Zun Zar Chi Naing,Yuan Zhou,Shiming Peng,Ying Shi,Ziyang Zhang,Wenqi Shen,Ilsa T Kirby,James E. Melnyk,John S. Chorba,Kevin Lou,Shizhong Dai,Inigo Barrio-Hernandez,Danish Memon,Claudia Hernandez-Armenta,Jiankun Lyu,Christopher J.P. Mathy,Tina Perica,Kala Bharath Pilla,Sai J. Ganesan,Daniel J. Saltzberg,Rakesh Ramachandran,Xi Liu,Sara Brin Rosenthal,Lorenzo Calviello,Srivats Venkataramanan,Jose Liboy-Lugo,Yizhu Lin,Xi Ping Huang,Yongfeng Liu,Stephanie A. Wankowicz,Markus Bohn,Maliheh Safari,Fatima S. Ugur,Cassandra Koh,Nastaran Sadat Savar,Quang Dinh Tran,Djoshkun Shengjuler,Sabrina J. Fletcher,Michael C. O’Neal,Yiming Cai,Jason C.J. Chang,David J. Broadhurst,Saker Klippsten,Phillip P. Sharp,Nicole A. Wenzell,Duygu Kuzuoğlu-Öztürk,Hao-Yuan Wang,Raphael Trenker,Janet M. Young,Devin A. Cavero,Devin A. Cavero,Joseph Hiatt,Joseph Hiatt,Theodore L. Roth,Ujjwal Rathore,Ujjwal Rathore,Advait Subramanian,Julia Noack,Mathieu Hubert,Robert M. Stroud,Alan D. Frankel,Oren S. Rosenberg,Kliment A. Verba,David A. Agard,Melanie Ott,Michael Emerman,Natalia Jura,Mark von Zastrow,Eric Verdin,Eric Verdin,Alan Ashworth,Olivier Schwartz,Christophe d'Enfert,Shaeri Mukherjee,Matthew P. Jacobson,Harmit S. Malik,Danica Galonić Fujimori,Trey Ideker,Charles S. Craik,Stephen N. Floor,James S. Fraser,John D. Gross,Andrej Sali,Bryan L. Roth,Davide Ruggero,Jack Taunton,Tanja Kortemme,Pedro Beltrao,Marco Vignuzzi,Adolfo García-Sastre,Kevan M. Shokat,Brian K. Shoichet,Nevan J. Krogan +128 more
TL;DR: A human–SARS-CoV-2 protein interaction map highlights cellular processes that are hijacked by the virus and that can be targeted by existing drugs, including inhibitors of mRNA translation and predicted regulators of the sigma receptors.
Posted ContentDOI
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing
David E. Gordon,Gwendolyn M. Jang,Mehdi Bouhaddou,Jiewei Xu,Kirsten Obernier,Jeffrey Z. Guo,Danielle L. Swaney,Tia A. Tummino,Tia A. Tummino,Ruth Hüttenhain,Robyn M. Kaake,Alicia L. Richards,Beril Tutuncuoglu,Helene Foussard,Jyoti Batra,Kelsey M. Haas,Maya Modak,Minkyu Kim,Paige Haas,Benjamin J. Polacco,Hannes Braberg,Jacqueline M. Fabius,Manon Eckhardt,Margaret Soucheray,Melanie J. Bennett,Merve Cakir,Michael McGregor,Qiongyu Li,Zun Zar Chi Naing,Yuan Zhou,Shiming Peng,Shiming Peng,Ilsa T Kirby,Ilsa T Kirby,James E. Melnyk,James E. Melnyk,John S. Chorba,John S. Chorba,Kevin Lou,Kevin Lou,Shizhong Dai,Shizhong Dai,Wenqi Shen,Wenqi Shen,Ying Shi,Ying Shi,Ziyang Zhang,Ziyang Zhang,Inigo Barrio-Hernandez,Danish Memon,Claudia Hernandez-Armenta,Christopher J.P. Mathy,Tina Perica,Tina Perica,Kala Bharath Pilla,Kala Bharath Pilla,Sai J. Ganesan,Sai J. Ganesan,Daniel J. Saltzberg,Daniel J. Saltzberg,Rakesh Ramachandran,Rakesh Ramachandran,Xi Liu,Xi Liu,Sara Brin Rosenthal,Lorenzo Calviello,Srivats Venkataramanan,Jose Liboy-Lugo,Yizhu Lin,Stephanie A. Wankowicz,Markus Bohn,Phillip P. Sharp,Raphael Trenker,Janet M. Young,Devin A. Cavero,Joseph Hiatt,Joseph Hiatt,Theodore L. Roth,Theodore L. Roth,Ujjwal Rathore,Advait Subramanian,Julia Noack,Mathieu Hubert,Ferdinand Roesch,Thomas Vallet,Bjoern Meyer,Kris M. White,Lisa Miorin,Oren S. Rosenberg,Kliment A. Verba,Kliment A. Verba,David A. Agard,Melanie Ott,Melanie Ott,Michael Emerman,Davide Ruggero,Davide Ruggero,Adolfo García-Sastre,Natalia Jura,Mark von Zastrow,Jack Taunton,Alan Ashworth,Olivier Schwartz,Marco Vignuzzi,Shaeri Mukherjee,Matthew P. Jacobson,Harmit S. Malik,Danica Galonić Fujimori,Danica Galonić Fujimori,Trey Ideker,Charles S. Craik,Stephen N. Floor,James S. Fraser,James S. Fraser,John D. Gross,John D. Gross,Andrej Sali,Tanja Kortemme,Pedro Beltrao,Kevan M. Shokat,Kevan M. Shokat,Brian K. Shoichet,Brian K. Shoichet,Nevan J. Krogan +123 more
TL;DR: The identification of host dependency factors mediating virus infection may provide key insights into effective molecular targets for developing broadly acting antiviral therapeutics against SARS-CoV-2 and other deadly coronavirus strains.
Journal ArticleDOI
CIS is a potent checkpoint in NK cell–mediated tumor immunity
Rebecca B. Delconte,Tatiana B. Kolesnik,Laura F. Dagley,Laura F. Dagley,Jai Rautela,Jai Rautela,Wei Shi,Wei Shi,Eva Maria Putz,Kimberley Stannard,Jian-Guo Zhang,Jian-Guo Zhang,Charis E Teh,Charis E Teh,Matthew A. Firth,Matthew A. Firth,Takashi Ushiki,Takashi Ushiki,Christopher E. Andoniou,Mariapia A. Degli-Esposti,Phillip P. Sharp,Phillip P. Sharp,C. Sanvitale,Giuseppe Infusini,Nicholas P. D. Liau,Nicholas P. D. Liau,Edmond M. Linossi,Edmond M. Linossi,Christopher J. Burns,Christopher J. Burns,Sebastian Carotta,Sebastian Carotta,Daniel H.D. Gray,Daniel H.D. Gray,Cyril Seillet,Cyril Seillet,Dana S. Hutchinson,Gabrielle T. Belz,Gabrielle T. Belz,Andrew I. Webb,Andrew I. Webb,Warren S. Alexander,Warren S. Alexander,Shawn S.-C. Li,Alex N. Bullock,Jeffery J. Babon,Jeffery J. Babon,Mark J. Smyth,Mark J. Smyth,Sandra E. Nicholson,Sandra E. Nicholson,Nicholas D. Huntington,Nicholas D. Huntington +52 more
TL;DR: This work has identified cytokine-inducible SH2-containing protein (CIS, encoded by Cish) as a critical negative regulator of IL-15 signaling in NK cells, and uncovered a potent intracellular checkpoint in NK cell–mediated tumor immunity.
Journal ArticleDOI
Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis
Priya S. Shah,Nichole Link,Gwendolyn M. Jang,Gwendolyn M. Jang,Phillip P. Sharp,Tongtong Zhu,Danielle L. Swaney,Danielle L. Swaney,Jeffrey R. Johnson,Jeffrey R. Johnson,John Von Dollen,John Von Dollen,Holly Ramage,Laura Satkamp,Laura Satkamp,Billy W. Newton,Billy W. Newton,Ruth Hüttenhain,Ruth Hüttenhain,Marine J. Petit,Tierney Baum,Amanda Everitt,Orly Laufman,Michel Tassetto,Michael Shales,Michael Shales,Erica Stevenson,Erica Stevenson,Gabriel N. Iglesias,Leila Shokat,Leila Shokat,Shashank Tripathi,Vinod Balasubramaniam,Laurence G. Webb,Sebastian Aguirre,A. Jeremy Willsey,Adolfo García-Sastre,Katherine S. Pollard,Sara Cherry,Andrea V. Gamarnik,Ivan Marazzi,Jack Taunton,Ana Fernandez-Sesma,Hugo J. Bellen,Raul Andino,Nevan J. Krogan,Nevan J. Krogan +46 more
TL;DR: Comparison of flavivirus-host PPI mapping provides biological insights and, when coupled with in vivo models, can be used to unravel pathogenic mechanisms.
Journal ArticleDOI
BET bromodomain inhibitors: a patent review
TL;DR: There is now compelling preclinical data demonstrating BET inhibition as a strategy to target processes known to be involved in disease development and progression with clinical trials of two bona fide BET inhibitors now underway.