Journal ArticleDOI
Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment
Dar Meshi,Michael R. Drew,Michael Saxe,Mark S. Ansorge,Denis J. David,Luca Santarelli,Chariklia Malapani,Holly Moore,René Hen +8 more
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TLDR
It is reported that environmental enrichment alters behavior in mice regardless of their hippocampal neurogenic capability, providing evidence that the newborn cells do not mediate these effects of enrichment.Abstract:
Environmental enrichment increases adult hippocampal neurogenesis and alters hippocampal-dependent behavior in rodents. To investigate a causal link between these two observations, we analyzed the effect of enrichment on spatial learning and anxiety-like behavior while blocking adult hippocampal neurogenesis. We report that environmental enrichment alters behavior in mice regardless of their hippocampal neurogenic capability, providing evidence that the newborn cells do not mediate these effects of enrichment.read more
Citations
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Mechanisms and functional implications of adult neurogenesis.
TL;DR: The factors that regulate proliferation and fate determination of adult neural stem cells are discussed and the potential significance of adult neurogenesis in memory, depression, and neurodegenerative disorders such as Alzheimer's and Parkinson's disease is addressed.
Journal ArticleDOI
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
TL;DR: Recent progress in the integration of adult-born neurons into the circuitry of the adult hippocampus suggests an important role for adult hippocampal neurogenesis in learning and memory, but its specific function in these processes has remained elusive.
Journal ArticleDOI
Enriched environments, experience-dependent plasticity and disorders of the nervous system.
TL;DR: Findings on the environmental modulators of pathogenesis and gene–environment interactions in CNS disorders, and their therapeutic implications, are reviewed.
Journal ArticleDOI
Adult hippocampal neurogenesis in depression.
Amar Sahay,René Hen +1 more
TL;DR: The functional differentiation of the hippocampus along the septo-temporal axis is revisited and it is suggested that neurogenesis in the ventral dentate gyrus may be preferentially involved in regulation of emotion.
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Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus
Michael Saxe,Fortunato Battaglia,Jingwen Wang,Gaël Malleret,Denis J. David,James E. Monckton,A. Denise R. Garcia,Michael V. Sofroniew,Eric R. Kandel,Luca Santarelli,René Hen,Michael R. Drew +11 more
TL;DR: The findings show that adult-born neurons make a distinct contribution to some but not all hippocampal functions and show that new hippocampal neurons can be preferentially recruited over mature granule cells in vitro and may provide a framework for how this small cell population can influence behavior.
References
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Journal ArticleDOI
Mammalian neural stem cells.
TL;DR: Before the full potential of neural stem cells can be realized, the authors need to learn what controls their proliferation, as well as the various pathways of differentiation available to their daughter cells.
Journal ArticleDOI
Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
Luca Santarelli,Michael Saxe,Cornelius Gross,Alexandre Surget,Fortunato Battaglia,Stephanie C. Dulawa,Noelia V. Weisstaub,James T. Lee,Ronald S. Duman,Ottavio Arancio,Catherine Belzung,René Hen +11 more
TL;DR: It is shown that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants, suggesting that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neuroGenesis in the hippocampus.
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More hippocampal neurons in adult mice living in an enriched environment
TL;DR: It is shown that significantly more new neurons exist in the dentate gyrus of mice exposed to an enriched environment compared with littermates housed in standard cages, and that the enriched mice have a larger hippocampal granule cell layer and 15 per cent moregranule cell neurons in the Dentate Gyrus.
Journal ArticleDOI
Neural consequences of environmental enrichment.
TL;DR: This article focuses on the neuronal changes that occur in response to complex stimulation by an enriched environment and emphasizes the behavioural and neurobiological consequences of specific elements of enrichment, especially exercise and learning.
The neuropsychology of anxiety
TL;DR: This paper is a rough precis of a recent book concerned with the question: what are the brain structures which mediate the psychology as well as the neurology of anxiety?