M
Michael Reuter
Researcher at University of Grenoble
Publications - 12
Citations - 1715
Michael Reuter is an academic researcher from University of Grenoble. The author has contributed to research in topics: Piwi-interacting RNA & Argonaute. The author has an hindex of 11, co-authored 12 publications receiving 1533 citations. Previous affiliations of Michael Reuter include European Bioinformatics Institute & Centre national de la recherche scientifique.
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Journal ArticleDOI
Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing
Michael Reuter,Philipp Berninger,Shinichiro Chuma,Hardik Shah,Mihoko Hosokawa,Charlotta Funaya,Claude Antony,Ravi Sachidanandam,Ramesh S. Pillai +8 more
TL;DR: It is shown that Miwi is a small RNA-guided RNase (slicer) that requires extensive complementarity for target cleavage in vitro and supports a slicer-dependent silencing mechanism that functions without piRNA amplification.
Journal ArticleDOI
The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline.
Masanobu Shoji,Takashi Tanaka,Mihoko Hosokawa,Michael Reuter,Alexander Stark,Yuzuru Kato,Gen Kondoh,Katsuya Okawa,Takeshi Chujo,Tsutomu Suzuki,Kenichiro Hata,Sandra L. Martin,Toshiaki Noce,Satomi Kuramochi-Miyagawa,Toru Nakano,Hiroyuki Sasaki,Ramesh S. Pillai,Norio Nakatsuji,Shinichiro Chuma +18 more
TL;DR: It is shown that tudor-domain containing 9 (Tdrd9) is essential for silencing Line-1 retrotransposon in the mouse male germline, and the results identify TDRD9 as a functional partner of MIWI2 and indicate that the tUDor-piwi association is a conserved feature.
Journal ArticleDOI
Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile.
Michael Reuter,Shinichiro Chuma,Takashi Tanaka,Thomas Franz,Alexander Stark,Ramesh S. Pillai +5 more
TL;DR: This work isolated Mili-containing complexes from adult mouse testes and identified Tudor domain–containing protein-1 (Tdrd1) as a factor specifically associated with the Mili piRNP throughout spermatogenesis, suggesting that Tdrd 1 ensures the entry of correct transcripts into the normal piRNA pool.
Journal ArticleDOI
Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway
Ke Zheng,Jordi Xiol,Michael Reuter,Sigrid Eckardt,N. Adrian Leu,K. John McLaughlin,Alexander Stark,Ravi Sachidanandam,Ramesh S. Pillai,Peijing Jeremy Wang +9 more
TL;DR: It is demonstrated that MOV10L1, a germ cell–specific putative RNA helicase, is associated with Piwi proteins, suggesting that MOV 10L1 is required for piRNA biogenesis and/or loading to PiWI proteins.
Journal ArticleDOI
Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis
Takashi Tanaka,Mihoko Hosokawa,Vasily V. Vagin,Michael Reuter,Eri Hayashi,Ayako L. Mochizuki,Kouichi Kitamura,Hidenori Yamanaka,Gen Kondoh,Katsuya Okawa,Satomi Kuramochi-Miyagawa,Toru Nakano,Ravi Sachidanandam,Gregory J. Hannon,Ramesh S. Pillai,Norio Nakatsuji,Shinichiro Chuma +16 more
TL;DR: It is delineated that chromatoid bodies assemble as an integrated compartment incorporating both germline and ubiquitous features as spermatogenesis proceeds and that the conserved tudor family genes act as master regulators of this unique RNP remodeling, which is genetically linked to the male germline integrity in mammals.