Takashi Tanaka

TL;DR: It is shown that tudor-domain containing 9 (Tdrd9) is essential for silencing Line-1 retrotransposon in the mouse male germline, and the results identify TDRD9 as a functional partner of MIWI2 and indicate that the tUDor-piwi association is a conserved feature.

TL;DR: This work isolated Mili-containing complexes from adult mouse testes and identified Tudor domain–containing protein-1 (Tdrd1) as a factor specifically associated with the Mili piRNP throughout spermatogenesis, suggesting that Tdrd 1 ensures the entry of correct transcripts into the normal piRNA pool.

TL;DR: The results indicate that Hex plays an essential role in progenitor cells which commit to the hepatic endoderm and in the hematopoietic differentiation of the monocyte lineage.

TL;DR: It is reported that Mili specifically interacts with Tudor domain-containing protein 1 (Tdrd1), a germline protein that contains multiple Tudor domains and represents a regulatory mechanism that is critical for spermatogenesis.

TL;DR: Results indicate that the Tudor-related proteins constitute an evolutionarily conserved class of nuage components in the germ-line, and their localization or accumulation to nuage is likely conferred by a Tudor domain structure and downstream of Mvh, while the characteristic repeated architecture of the domain is functionally essential for the differentiation of germ cells.