M
Michael T. Zimmermann
Researcher at Medical College of Wisconsin
Publications - 129
Citations - 3540
Michael T. Zimmermann is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Exome sequencing & Exome. The author has an hindex of 25, co-authored 124 publications receiving 2610 citations. Previous affiliations of Michael T. Zimmermann include Iowa State University & Mayo Clinic.
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Journal ArticleDOI
Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas
Theo A. Knijnenburg,Linghua Wang,Michael T. Zimmermann,Nyasha Chambwe,Galen F. Gao,Andrew D. Cherniack,Huihui Fan,Hui Shen,Gregory P. Way,Casey S. Greene,Yuexin Liu,Rehan Akbani,Bin Feng,Lawrence A. Donehower,Chase Miller,Yang Shen,Mostafa Karimi,Haoran Chen,Pora Kim,Peilin Jia,Eve Shinbrot,Shaojun Zhang,Jianfang Liu,Hai Hu,Matthew H. Bailey,Christina Yau,Denise M. Wolf,Zhongming Zhao,John N. Weinstein,Lei Li,Li Ding,Gordon B. Mills,Peter W. Laird,David A. Wheeler,Ilya Shmulevich,Raymond J. Monnat,Yonghong Xiao,Chen Wang +37 more
TL;DR: These frequent DDR gene alterations in many human cancers have functional consequences that may determine cancer progression and guide therapy and a new machine-learning-based classifier developed from gene expression data allowed to identify alterations that phenocopy deleterious TP53 mutations.
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Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport
Feng Long,Chih-Chia Su,Michael T. Zimmermann,Scott E. Boyken,Kanagalaghatta R. Rajashankar,Robert L. Jernigan,Edward W. Yu +6 more
TL;DR: The crystal structure indicates that CusA has, in addition to the three-methionine metal-binding site, four methionine pairs—three located in the transmembrane region and one in the periplasmic domain, which directly suggests a plausible pathway for ion export.
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Endothelin concentrations in patients with aneurysmal subarachnoid hemorrhage. Correlation with cerebral vasospasm, delayed ischemic neurological deficits, and volume of hematoma.
TL;DR: The volume of hematoma in the basal cisterns as detected by computerized tomography was predictive of the concentrations of ETs in the CSF, and the temporal dependence of concentrations of big ET-1 andET-1 in SAH patients with and without CVS were significantly different.
Journal ArticleDOI
Crystal structure of the CusBA heavy-metal efflux complex of Escherichia coli
Chih-Chia Su,Feng Long,Michael T. Zimmermann,Kanagalaghatta R. Rajashankar,Robert L. Jernigan,Edward W. Yu +5 more
TL;DR: The co-crystal structure of the CusBA efflux complex is reported, showing that the transporter (or pump) CusA, which is present as a trimer, interacts with six CusB protomers and that the periplasmic domain of CUSA is involved in these interactions.
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Relative importance of hypertension compared with hypervolemia for increasing cerebral oxygenation in patients with cerebral vasospasm after subarachnoid hemorrhage
TL;DR: In poor-grade patients, moderate hypertension in a normovolemic, hemodiluted patient is an effective method of improving cerebral oxygenation and is associated with a lower complication rate compared with hypervolemia or aggressive hypertension therapy.