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Chase Miller
Researcher at University of Utah
Publications - 21
Citations - 1372
Chase Miller is an academic researcher from University of Utah. The author has contributed to research in topics: Exome & Gene. The author has an hindex of 11, co-authored 18 publications receiving 980 citations. Previous affiliations of Chase Miller include George Washington University & Baylor College of Medicine.
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Journal ArticleDOI
Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas
Theo A. Knijnenburg,Linghua Wang,Michael T. Zimmermann,Nyasha Chambwe,Galen F. Gao,Andrew D. Cherniack,Huihui Fan,Hui Shen,Gregory P. Way,Casey S. Greene,Yuexin Liu,Rehan Akbani,Bin Feng,Lawrence A. Donehower,Chase Miller,Yang Shen,Mostafa Karimi,Haoran Chen,Pora Kim,Peilin Jia,Eve Shinbrot,Shaojun Zhang,Jianfang Liu,Hai Hu,Matthew H. Bailey,Christina Yau,Denise M. Wolf,Zhongming Zhao,John N. Weinstein,Lei Li,Li Ding,Gordon B. Mills,Peter W. Laird,David A. Wheeler,Ilya Shmulevich,Raymond J. Monnat,Yonghong Xiao,Chen Wang +37 more
TL;DR: These frequent DDR gene alterations in many human cancers have functional consequences that may determine cancer progression and guide therapy and a new machine-learning-based classifier developed from gene expression data allowed to identify alterations that phenocopy deleterious TP53 mutations.
Journal ArticleDOI
Taxonomer: an interactive metagenomics analysis portal for universal pathogen detection and host mRNA expression profiling.
Steven Flygare,Keith E. Simmon,Chase Miller,Yi Qiao,Brett Kennedy,Tonya Di Sera,Erin H. Graf,Keith D. Tardif,Aurélie Kapusta,Shawn Rynearson,Chris Stockmann,Krista Queen,Suxiang Tong,Karl V. Voelkerding,Karl V. Voelkerding,Anne J. Blaschke,Carrie L. Byington,Seema Jain,Andrew T. Pavia,Kwabena Krow Ampofo,Karen Eilbeck,Gabor T. Marth,Mark Yandell,Robert Schlaberg,Robert Schlaberg +24 more
TL;DR: It is shown that Taxonomer detects previously unrecognized infections and reveals antiviral host mRNA expression profiles and enables rapid, accurate, and interactive analyses of metagenomics data on personal computers and mobile devices.
Journal ArticleDOI
Scotty: a web tool for designing RNA-Seq experiments to measure differential gene expression
TL;DR: Scotty is an interactive web-based application that assists biologists to design an experiment with an appropriate sample size and read depth to satisfy the user-defined experimental objectives.
Journal ArticleDOI
Sp185/333: A novel family of genes and proteins involved in the purple sea urchin immune response
Julie Ghosh,Katherine M. Buckley,Sham V. Nair,David A. Raftos,Chase Miller,Audrey J. Majeske,Taku Hibino,Jonathan P. Rast,Mattias O. Roth,L. Courtney Smith +9 more
TL;DR: The Sp185/333 system of genes, messages and proteins are expressed in the coelomocytes of the purple sea urchin, Strongylocentrotus purpuratus, and is an extraordinary example of diversification of a putative innate immune response system in an invertebrate.
Journal ArticleDOI
Whole-genome analysis for effective clinical diagnosis and gene discovery in early infantile epileptic encephalopathy.
Betsy Ostrander,Russell J. Butterfield,Brent S. Pedersen,Andrew J. Farrell,Ryan M. Layer,Alistair Ward,Chase Miller,Tonya DiSera,Francis Filloux,Meghan Candee,Tara M. Newcomb,Joshua L. Bonkowsky,Gabor T. Marth,Aaron R. Quinlan +13 more
TL;DR: The research team thoroughly detailed the genomic variation of 14 babies with early infantile epileptic encephalopathy, finding mutations causing severe newborn seizures and suggesting that whole-genome testing could be a cost-effective approach to diagnosing EIEE and other genetic conditions.