Michal J. Nagiec

TL;DR: The genome of a genetically representative strain of serotype M28 strains has genes encoding a novel array of prophage virulence factors, cell-surface proteins, and other molecules likely to contribute to host-pathogen interactions.

TL;DR: A serotype M3 clone significantly underrepresented among necrotizing fasciitis cases has a unique frameshift mutation that truncates MtsR, a transcriptional regulator controlling expression of genes encoding iron-acquisition proteins, which provided unprecedented detail about the molecular anatomy of bacterial strain genotype-patient phenotype relationships.

TL;DR: It is proposed that scaffold proteins serve to modulate the temporal and dose-response behavior of the MAP kinase, and thus help cells respond to a gradient or mate efficiently with distant partners.

TL;DR: A system-wide view of phosphorylation events downstream of SDF-1/CXCR4 signaling in breast CSCs is given, providing a resource for the study of CSC-targeted cancer therapy and identifying several previously unidentified phosphoproteins and signaling pathways in Breast cancer stem cells.

TL;DR: It is reported that the transcription factor forkhead/winged helix family k1 (Foxk1) is a mediator of mTORC1-regulated gene expression and is likely to be critical for metabolic diseases where improper m TORC1 signaling plays an important role.