M
Michel Jadot
Researcher at Université de Namur
Publications - 75
Citations - 3150
Michel Jadot is an academic researcher from Université de Namur. The author has contributed to research in topics: Lysosome & Mannose 6-phosphate receptor. The author has an hindex of 25, co-authored 72 publications receiving 2912 citations. Previous affiliations of Michel Jadot include University of Liège.
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Journal ArticleDOI
Identification of HE1 as the Second Gene of Niemann-Pick C Disease
Saule Naureckiene,David E. Sleat,David E. Sleat,Henry Lackland,Anthony H. Fensom,Marie T. Vanier,Robert Wattiaux,Michel Jadot,Peter Lobel,Peter Lobel +9 more
TL;DR: Treatment of NP-C2 fibroblasts with exogenous recombinant HE1 protein ameliorated lysosomal accumulation of low density lipoprotein-derived cholesterol.
Journal ArticleDOI
Endosomes, lysosomes: their implication in gene transfer.
TL;DR: Different factors that could affect the trafficking of plasmid DNA and influence transfection efficiency are considered.
Journal ArticleDOI
An extended proteome map of the lysosomal membrane reveals novel potential transporters
Agnès Chapel,Sylvie Kieffer-Jaquinod,Sylvie Kieffer-Jaquinod,Sylvie Kieffer-Jaquinod,Corinne Sagné,Quentin Verdon,Quentin Verdon,Corinne Ivaldi,Corinne Ivaldi,Corinne Ivaldi,Mourad Mellal,Mourad Mellal,Mourad Mellal,Jaqueline Thirion,Michel Jadot,Christophe Bruley,Christophe Bruley,Christophe Bruley,Jérôme Garin,Jérôme Garin,Jérôme Garin,Bruno Gasnier,Agnès Journet,Agnès Journet,Agnès Journet +24 more
TL;DR: A comparative, semi-quantitative proteomic analysis of rat liver lysosome-enriched and lysOSome-nonenriched membranes and used spectral counts to evaluate the relative abundance of proteins substantially increases knowledge of the lYSosomal membrane and provides a basis for further characterization of lyssomal functions.
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Intralysosomal hydrolysis of glycyl-l-phenylalanine 2-naphthylamide
TL;DR: Evidence is presented that Gly-L-Phe-2-NNap can possibly cause a disruption of the lysosomes as a result of its hydrolysis inside these organelles, and the usefulness of this enzyme and related dipeptidyl naphthylamides in lysOSomal-membrane-permeability studies is emphasized.
Journal ArticleDOI
Expression of Lamp-1 and Lamp-2 and their interactions with galectin-3 in human tumor cells
V. Sarafian,Michel Jadot,Jean-Michel Foidart,Jean-Jacques Letesson,F. Van Den Brule,Vincenzo Castronovo,Robert Wattiaux,Simone Wattiaux-De Coninck +7 more
TL;DR: The results support the idea that Lamps may be considered a new family of adhesive glycoproteins participating in the complex process of tumor invasion and metastasis.