M
Michel Lanotte
Researcher at French Institute of Health and Medical Research
Publications - 81
Citations - 6625
Michel Lanotte is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Acute promyelocytic leukemia & Cellular differentiation. The author has an hindex of 38, co-authored 73 publications receiving 6454 citations. Previous affiliations of Michel Lanotte include Centre national de la recherche scientifique & Fudan University Shanghai Medical College.
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The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus
TL;DR: It is reported that, in one APL-derived cell line, the RARα gene has been translocated to a locus, myl, on chromosome 15, resulting in the synthesis of a myl/RARα fusion messenger RNA, which strongly implicate retinoic acid receptor α in leukaemogenesis.
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NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3)
TL;DR: In vitro and in vivo studies suggest that all-trans retinoic acid (RA) treatment restores cell maturation, and the first permanent cell line with t(15;17), derived from the marrow of a patient with APL in relapse is isolated.
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Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins.
Philippe Kastner,A. Perez,Yves Lutz,Cécile Rochette-Egly,Marie-Pierre Gaub,Bénédicte Durand,Michel Lanotte,R. Berger,Pierre Chambon +8 more
TL;DR: The characterization of Myl and of the reciprocal MylRAR (PMLRAR) and RARMyl (RARPML) fusion transcripts which are found in two classes of APL patients suggest that MyLRAR may interfere in a dominant manner with both MyL and RAR functions.
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The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells.
Roald Bøe,Bjørn Tore Gjertsen,Olav Karsten Vintermyr,Gunnar Houge,Michel Lanotte,Stein Ove Døskeland +5 more
TL;DR: The treated cells had no swollen mitochondria and retained the ability to exclude trypan blue until the final stage of dissolution, supporting the hypothesis that the changes were apoptotic rather than necrotic.
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Gene expression networks underlying retinoic acid–induced differentiation of acute promyelocytic leukemia cells
Ting Xi Liu,Jiwang Zhang,Jiong Tao,Ruo-Bo Zhang,Qinghua Zhang,Chunjun Zhao,Jian-Hua Tong,Michel Lanotte,Samuel Waxman,Sai-Juan Chen,Mao Mao,Geng-Xi Hu,Li Zhu,Zhu Chen +13 more
TL;DR: A balanced functional network seemed to emerge, and it formed the foundation of decreased cellular proliferation, maintenance of cell viability, increased protein modulation, and promotion of granulocytic maturation.