M
Michio Murata
Researcher at Osaka University
Publications - 299
Citations - 11594
Michio Murata is an academic researcher from Osaka University. The author has contributed to research in topics: Maitotoxin & Lipid bilayer. The author has an hindex of 50, co-authored 288 publications receiving 10668 citations. Previous affiliations of Michio Murata include Kitasato University & Tohoku University.
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Journal ArticleDOI
Convergent Synthesis of the CDEF Ring Fragment of Yessotoxin via α-Cyano Ethers
TL;DR: The CDEF ring fragment of yessotoxin, a marine ladder polyether, has been synthesized in this paper using Sc(OTf) 3 to afford the α-cyano ether both in stepwise and one-pot reactions.
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Maitotoxin-photoactive probe binds to membrane proteins in blood cells
Keiichi Konoki,Keiichi Konoki,Masaki Hashimoto,Kaori Honda,Kazuo Tachibana,Rie Tamate,Futoshi Hasegawa,Tohru Oishi,Michio Murata +8 more
TL;DR: Screening of polyether compounds for MTX inhibitory activity using Ca 2+ flux assays in C6 cells disclosed that a synthetic fragment of the hydrophilic portion of MTX inhibited the MTX activity.
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Detection of Rap1A as a yessotoxin binding protein from blood cell membranes
Satoru Ujihara,Tohru Oishi,Tohru Oishi,Ryota Mouri,Rie Tamate,Keiichi Konoki,Nobuaki Matsumori,Michio Murata,Yasukatsu Oshima,Naoyuki Sugiyama,Masaru Tomita,Yasushi Ishihama +11 more
TL;DR: HPLC-tandem mass spectrometry indicated that Rap 1A, one of Ras superfamily proteins, binds to the YTX-linked resins, and western blotting and surface plasmon resonance experiments confirmed that Rap1A specifically binds to YTX with the K(D) value around 4 μM.
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Ion channel complex of antibiotics as viewed by NMR
Michio Murata,Yusuke Kasai,Yuichi Umegawa,Naohiro Matsushita,Hiroshi Tsuchikawa,Nobuaki Matsumori,Tohru Oishi +6 more
TL;DR: Using rotor-synchronous double resonance experiments such as REDOR and RDX, it is estimated that the distance between the fluorine atom and its nearest carbon in the heptaene moiety to be less than 8.6 Å, indicating that the B ring of ergosterol comes close to the AmB polyenes moiety.
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Cholesterol-Induced Conformational Change in the Sphingomyelin Headgroup.
Shinya Hanashima,Kazuhiro Murakami,Michihiro Yura,Yo Yano,Yuichi Umegawa,Hiroshi Tsuchikawa,Nobuaki Matsumori,Sangjae Seo,Wataru Shinoda,Michio Murata +9 more
TL;DR: The conformational ensemble in the presence of Cho may enhance the so-called umbrella effect of the SSM headgroup, resulting in the stabilization of Cho near the SM molecules by concealing the hydrophobic Cho core from interfacial water.