Michio Murata

TL;DR: Clear distinction between the C(12) and C(14) lipids implies that molecular interaction between phospholipid and AmB is partly due to the matching of their hydrophobic length.

TL;DR: A newly developed calorimetric method is employed for comprehensively evaluating the affinity of FAs, sub-Angstrom X-ray crystallography to accurately determine their 3D structure, and energy calculations of the coexisting water molecules using the computer program WaterMap to gain a general understanding of how proteins recognize diverse lipids with different chain lengths.

TL;DR: Cloning of polyether polyketide synthase (PKS) genes for salinomycin biosynthetic gene cluster of Streptomyces albus showed high homology with bacterial type I PKSs and was deduced to code for KS, malonyl transferase, and ketoreductase motifs.

TL;DR: The model of the three-dimensional conformation of OA appears to be present in a position relatively free from intramolecular bonding formation, in comparison with the other three hydroxyl groups, which may imply that the 27-hydroxyl group serves as a binding site with the phosphatase molecules.

TL;DR: This study demonstrates that TNM-A directly recognizes the 3β-OH moiety of sterols, which greatly facilitates its binding to bilayer membranes.