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Yoshihiko Otsuka
Publications - 7
Citations - 549
Yoshihiko Otsuka is an academic researcher. The author has contributed to research in topics: Curcumin & Pharmacokinetics. The author has an hindex of 5, co-authored 7 publications receiving 449 citations.
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Journal ArticleDOI
Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers
Masashi Kanai,Atsushi Imaizumi,Yoshihiko Otsuka,Hiroki Sasaki,Momo Hashiguchi,Kazu Tsujiko,Shigemi Matsumoto,Hiroshi Ishiguro,Tsutomu Chiba +8 more
TL;DR: THERACURMIN can safely increase plasma curcumin levels in a dose-dependent manner at least up to 210 mg without saturating the absorption system, and is the first nanoparticle formulation ofCurcumin that demonstrates improved bioavailability in human subjects.
Journal ArticleDOI
A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin®) in cancer patients
Masashi Kanai,Yoshihiko Otsuka,Kazunori Otsuka,Maremi Sato,Takafumi Nishimura,Yukiko Mori,Michiya Kawaguchi,Etsuro Hatano,Yuzo Kodama,Shigemi Matsumoto,Yoshiki Murakami,Atsushi Imaizumi,Tsutomu Chiba,Jun Nishihira,Hiroyuki Shibata +14 more
TL;DR: Repetitive systemic exposure to high concentrations of curcumin achieved by Theracurmin® did not increase the incidence of adverse events in cancer patients receiving gemcitabine-based chemotherapy.
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Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin
Yoko Tanabe,Seiji Maeda,Nobuhiko Akazawa,Asako Zempo-Miyaki,Youngju Choi,Song-Gyu Ra,Atsushi Imaizumi,Yoshihiko Otsuka,Kazunori Nosaka +8 more
TL;DR: It is concluded that theracurmin ingestion attenuates some aspects of muscle damage such as MVC loss and CK activity increase.
Journal ArticleDOI
Curcumin attenuates oxidative stress following downhill running-induced muscle damage
Noriaki Kawanishi,Kouki Kato,Masaki Takahashi,Tsubasa Mizokami,Yoshihiko Otsuka,Atsushi Imaizumi,Daisuke Shiva,Hiromi Yano,Katsuhiko Suzuki +8 more
TL;DR: Curcumin may attenuate oxidative stress following downhill running-induced muscle damage and mRNA expression levels of MCP-1, CXCL14 and F4/80 reflecting presence of macrophages in the downhill running mice were significantly higher than those in the rest mice, but these variables were significantly attenuated by curcumin administration in downhillRunning mice.
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Drinkable Preparation of Theracurmin Exhibits High Absorption Efficiency—A Single-Dose, Double-Blind, 4-Way Crossover Study
Tatsuya Morimoto,Yoichi Sunagawa,Yasufumi Katanasaka,Sae Hirano,Masatoshi Namiki,Yuichi Watanabe,Hidetoshi Suzuki,Osamu Doi,Kiyomi Suzuki,Miyuki Yamauchi,Tsunehiro Yokoji,Eriko Miyoshi-Morimoto,Yoshihiko Otsuka,Tomoko Hamada,Atsushi Imaizumi,Yuji Nonaka,Takashi Fuwa,Takanori Teramoto,Hideaki Kakeya,Hiromichi Wada,Koji Hasegawa +20 more
TL;DR: Data indicate that the newly prepared Theracurmin beverage exhibits a much better absorption efficiency than other kinds of curcumin beverage sold in Japan.