M
Mimi Wan
Researcher at Yale University
Publications - 11
Citations - 1513
Mimi Wan is an academic researcher from Yale University. The author has contributed to research in topics: Chromatin & Chromatin remodeling. The author has an hindex of 8, co-authored 11 publications receiving 1388 citations. Previous affiliations of Mimi Wan include Howard Hughes Medical Institute & Stanford University.
Papers
More filters
Journal ArticleDOI
An Essential Switch in Subunit Composition of a Chromatin Remodeling Complex during Neural Development
Julie Lessard,Jiang Wu,Jeffrey A. Ranish,Mimi Wan,Monte M. Winslow,Brett T. Staahl,Hai Wu,Ruedi Aebersold,Isabella A. Graef,Gerald R. Crabtree +9 more
TL;DR: It is suggested that SWI/SNF-like complexes in vertebrates achieve biological specificity by combinatorial assembly of their subunits by preventing the subunit switch impairs neuronal differentiation.
Journal ArticleDOI
Genome-wide detection of DNase I hypersensitive sites in single cells and FFPE tissue samples
Wenfei Jin,Qingsong Tang,Mimi Wan,Kairong Cui,Yi Zhang,Yi Zhang,Gang Ren,Gang Ren,Bing Ni,Jeffrey Sklar,Teresa M. Przytycka,Richard W. Childs,David Levens,Keji Zhao +13 more
TL;DR: In this article, a single-cell DNase sequencing (scDNase-seq) strategy was proposed for detection of genome-wide hypersensitive sites (DHSs) in single cells.
Journal ArticleDOI
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes
TL;DR: The results indicate that BAF complexes contribute to lineage bifurcation by reciprocally regulating lineage-specific genes, reminiscent of the role of the yeast SWI/SNF complex in mediating mating-type switching.
Journal ArticleDOI
Sequential Roles of Brg, the ATPase Subunit of BAF Chromatin Remodeling Complexes, in Thymocyte Development
Tian Chi,Mimi Wan,Peggy P. Lee,Koichi Akashi,Daniel Metzger,Pierre Chambon,Christopher B. Wilson,Gerald R. Crabtree +7 more
TL;DR: It is shown that BAF complexes dynamically remodel chromatin to propel sequential developmental transitions in response to external signals, and that pre-TCR and potentially Wnt signaling pathways controlling the expression of genes such as c-Kit and c-Myc critical for continued development are disrupted.
Journal ArticleDOI
Induction of TLR4-target genes entails calcium/calmodulin-dependent regulation of chromatin remodeling
Dazhi Lai,Mimi Wan,Jie Wu,Paula Preston-Hurlburt,Ritu Kushwaha,Thomas Grundström,Anthony N. Imbalzano,Tian Chi +7 more
TL;DR: The data implicate calcium/CaM in TLR4 signaling, and reveal a previously undescribed, recruitment-independent mode of regulation of the BAF complex that is probably achieved through a direct CaM-BAF interaction.