M
Ming-Qiang Zheng
Researcher at Yale University
Publications - 79
Citations - 2250
Ming-Qiang Zheng is an academic researcher from Yale University. The author has contributed to research in topics: Radioligand & Binding potential. The author has an hindex of 24, co-authored 79 publications receiving 1793 citations. Previous affiliations of Ming-Qiang Zheng include Chinese Academy of Sciences.
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Journal ArticleDOI
Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study.
Alexander Neumeister,Marc D. Normandin,Marc D. Normandin,Robert H. Pietrzak,Robert H. Pietrzak,Daniele Piomelli,Ming-Qiang Zheng,Ana Gujarro-Anton,Marc N. Potenza,Christopher R. Bailey,Shu-fei Lin,Soheila Najafzadeh,Jim Ropchan,Shannan Henry,Stefani Corsi-Travali,Richard E. Carson,Yiyun Huang +16 more
TL;DR: It is suggested that abnormal CB1 receptor-mediated anandamide signaling is implicated in the etiology of PTSD, and provide a promising neurobiological model to develop novel, evidence-based pharmacotherapies for this disorder.
Journal ArticleDOI
Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma
Jiangbing Zhou,Toral R. Patel,Rachael W. Sirianni,Garth W. Strohbehn,Ming-Qiang Zheng,Nha Duong,Thomas Schafbauer,Anita Huttner,Yiyun Huang,Richard E. Carson,Ying Zhang,David J. Sullivan,Joseph M. Piepmeier,W. Mark Saltzman +13 more
TL;DR: A unique approach to controlled delivery in the brain should have a significant impact on treatment of glioblastoma multiforme and suggests previously undescribed routes for drug and gene delivery to treat other diseases of the central nervous system.
Journal ArticleDOI
Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging
Liang Han,Derek Kai Kong,Ming-Qiang Zheng,Sasidhar Murikinati,Chao Ma,Peng Yuan,Liyuan Li,Daofeng Tian,Qiang Cai,Chunlin Ye,Daniel Holden,June-Hee Park,Xiaobin Gao,Jean-Leon Thomas,Jaime Grutzendler,Richard E. Carson,Yiyun Huang,Joseph M. Piepmeier,Jiangbing Zhou +18 more
TL;DR: The results suggest ABTT NPs can prime the brain to increase the systemic delivery of therapeutics for treating brain malignancies.
Journal ArticleDOI
Synthesis and Evaluation of 11C-LY2795050 as a κ-Opioid Receptor Antagonist Radiotracer for PET Imaging
Ming-Qiang Zheng,Nabeel Nabulsi,Su Jin Kim,Giampaolo Tomasi,Shu-fei Lin,Charles H. Mitch,Steven James Quimby,Vanessa N. Barth,Karen S. Rash,John Joseph Masters,Antonio Navarro,Eric P. Seest,Evan D. Morris,Richard E. Carson,Yiyun Huang +14 more
TL;DR: This newly developed KOR antagonist tracer has since been advanced to PET imaging of KOR in humans and constitutes the first successful KOR antagonists radiotracer.
Journal ArticleDOI
Imaging the cannabinoid CB1 receptor in humans with [11C]OMAR: assessment of kinetic analysis methods, test-retest reproducibility, and gender differences.
Marc D. Normandin,Ming-Qiang Zheng,Kuo-Shyan Lin,N. Scott Mason,Shu-fei Lin,Jim Ropchan,David Labaree,Shannan Henry,Wendol Williams,Richard E. Carson,Alexander Neumeister,Yiyun Huang +11 more
TL;DR: Findings show that [11C]OMAR binding can be reliably quantified by the 2T model or MA1 method and demonstrate the utility of this tracer for in vivo imaging of CB1R and indicate that gender difference in receptor binding should be taken into consideration when it is used to quantifyCB1R availability in neuropsychiatric disorders.