Mingrong Zhang

TL;DR: Altered alterations in the gut, dental or saliva microbiome distinguished individuals with RA from healthy controls, were correlated with clinical measures and could be used to stratify individuals on the basis of their response to therapy.

TL;DR: This study provides the first evidence that HLA-DQα1:160D, instead of Hla-DRB1*0405, is the strongest and independent genetic risk for ACPA-positive RA in Han Chinese, and illustrates the value of deep sequencing for fine-mapping disease risk variants in the MHC region.

TL;DR: Wang et al. as mentioned in this paper performed a genetic association study of longevity in a total of 15,651 Chinese individuals and found that longevity was genetically causally correlated with reduced risks of multiple diseases, such as type 2 diabetes, cardiovascular diseases, and arthritis.

TL;DR: The genomewide association study and replication study with total of 174 cases and 1761 trichloroethylene-tolerant controls found two SNPs that exceeded the threshold for genome-wide significance and could be considered for translational application for screening employees before exposure.

TL;DR: In this paper , a review of the application of PET molecular imaging to date of systemic immune responses following ICI therapy and the associated rationale is presented, where the authors briefly review the application and rationale for using PET imaging to assess the systemic immune response elicited by immune checkpoint inhibitors to guide subsequent treatment regimens.