M
Mitchell E. Allen
Researcher at Virginia Tech
Publications - 10
Citations - 657
Mitchell E. Allen is an academic researcher from Virginia Tech. The author has contributed to research in topics: Cardioprotection & Mitochondrion. The author has an hindex of 6, co-authored 9 publications receiving 399 citations. Previous affiliations of Mitchell E. Allen include East Carolina University.
Papers
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Journal ArticleDOI
Expert consensus document: Mitochondrial function as a therapeutic target in heart failure
David Brown,Justin B. Perry,Mitchell E. Allen,Hani N. Sabbah,Hani N. Sabbah,Brian L. Stauffer,Saame Raza Shaikh,John G.F. Cleland,Wilson S. Colucci,Javed Butler,Adriaan A. Voors,Stefan D. Anker,Bertram Pitt,Bertram Pitt,Burkert Pieske,Gerasimos Filippatos,Stephen J. Greene,Mihai Gheorghiade +17 more
TL;DR: In this article, insights into the mechanisms of mitochondrial dysfunction in heart failure are presented, along with an overview of emerging treatments with the potential to improve the function of the failing heart by targeting mitochondria.
Journal ArticleDOI
Common gut microbial metabolites of dietary flavonoids exert potent protective activities in β-cells and skeletal muscle cells.
Benjamin F. Bitner,Jason D. Ray,Kyle B. Kener,Jacob A. Herring,Josie A. Tueller,Deborah K. Johnson,Claudia M. Tellez Freitas,Dane W. Fausnacht,Mitchell E. Allen,Alexander H. Thomson,K. Scott Weber,Ryan P. McMillan,Matthew W. Hulver,David Brown,Jeffery S. Tessem,Andrew P. Neilson +15 more
TL;DR: The present results demonstrate the activities of flavonoid microbial metabolites for preservation of β-cell function and glucose utilization and raise the intriguing prospect that bioavailability of native dietary flavonoids may not be as critical of a limiting factor to bioactivity as previously thought.
Journal ArticleDOI
The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats.
Mitchell E. Allen,Edward Ross Pennington,Edward Ross Pennington,Justin B. Perry,Sahil Dadoo,Marina Makrecka-Kuka,Maija Dambrova,Fatiha Moukdar,Hetal D. Patel,Xianlin Han,Grahame K. Kidd,Emily Benson,Tristan B. Raisch,Steven Poelzing,David Brown,Saame Raza Shaikh +15 more
TL;DR: The data suggest mitochondrial structure-function are interdependent and demonstrate elamipretide targets mitochondrial membranes to sustain cristae networks and improve bioenergetic function.
Journal ArticleDOI
Safety of drug use in patients with a primary mitochondrial disease: An international Delphi‐based consensus
Maaike de Vries,David Brown,Mitchell E. Allen,Laurence A. Bindoff,Laurence A. Bindoff,Grainne S. Gorman,Grainne S. Gorman,Amel Karaa,Nandaki Keshavan,Nandaki Keshavan,Costanza Lamperti,Robert McFarland,Robert McFarland,Yi Shiau Ng,Yi Shiau Ng,Mar O'Callaghan,Mar O'Callaghan,Robert D S Pitceathly,Shamima Rahman,Shamima Rahman,Frans G. M. Russel,Kristin N. Varhaug,Kristin N. Varhaug,Tom J.J. Schirris,Michelangelo Mancuso +24 more
TL;DR: The consensus guidelines of an expert panel are detailed and an important update of previously established guidelines in safe medication use in patients with primary mitochondrial disease is provided.
Journal ArticleDOI
Cardioprotective Effects of Mitochondria-Targeted Peptide SBT-20 in two Different Models of Rat Ischemia/Reperfusion
Wangde Dai,Wangde Dai,Elissa Cheung,Rick J. Alleman,Justin B. Perry,Mitchell E. Allen,David Brown,Robert A. Kloner,Robert A. Kloner +8 more
TL;DR: In this paper, the effects of mitochondria-targeted cytoprotective peptide SBT-20 on myocardial infarct size in two different models of ischemia/reperfusion were investigated.