S
Shinya Aramaki
Researcher at Kyoto University
Publications - 3
Citations - 1429
Shinya Aramaki is an academic researcher from Kyoto University. The author has contributed to research in topics: Induced pluripotent stem cell & Germline. The author has an hindex of 3, co-authored 3 publications receiving 1200 citations.
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Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells
TL;DR: The generation of primordial germ cell-like cells (PGCLCs) in mice with robust capacity for spermatogenesis is demonstrated and provided a paradigm for the first step of in vitro gametogenesis.
Journal ArticleDOI
A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants
Shinya Aramaki,Katsuhiko Hayashi,Kazuki Kurimoto,Hiroshi Ohta,Yukihiro Yabuta,Hiroko Iwanari,Yasuhiro Mochizuki,Takao Hamakubo,Yuki Kato,Katsuhiko Shirahige,Mitinori Saitou +10 more
TL;DR: It is shown that WNT3 induces many transcription factors associated with mesoderm in epiblast-like cells through β-CATENIN, and T (BRACHYURY), a classical and conserved mesodermal factor, was essential for robust activation of Blimp1 and Prdm14, two of the germline determinants.
Journal ArticleDOI
SC3-seq: a method for highly parallel and quantitative measurement of single-cell gene expression.
Tomonori Nakamura,Yukihiro Yabuta,Ikuhiro Okamoto,Shinya Aramaki,Shihori Yokobayashi,Kazuki Kurimoto,Kiyotoshi Sekiguchi,Masato Nakagawa,Takuya Yamamoto,Mitinori Saitou +9 more
TL;DR: The SC3-seq reveals the heterogeneity in human-induced pluripotent stem cells (hiPSCs) cultured under on-feeder as well as feeder-free conditions, demonstrating a more homogeneous property of the feeder -free hiPSCs.