Mitsuo Miyazawa

TL;DR: The present results show that there are sex-related differences in the oxidative metabolism of limonene enantiomers by liver microsomes, which may provide useful information on the basis ofLimonene-induced toxicities in different animal species.

TL;DR: The results of the sniffing test indicated that (E)-2-nonenal and eugenol were estimated to have a bamboo-like aroma, and aldehyde compounds, such as a phenylacetaldehyde (floral) and C9-C10 unsaturated aldehydes, make the aroma of bamboo.

TL;DR: Antimutagenic activity of compound 2 was found, which showed suppressive effects on umu gene expression of the SOS response to DNA damage in Salmonella typhimurium TA1535/pSK1002, induced by the chemical mutagens furylfuramide, MeIQ, and Trp-P-1.

TL;DR: Investigating whether (+)- and (-)-limonene enantiomers are differentially metabolized by P450 enzymes in liver microsomes of mice, rats, guinea pigs, rabbits, dogs, monkeys, and humans suggests that there are species-related differences in the metabolism of limonenes by P 450 enzymes.

TL;DR: The structures of metabolic products were determined by spectroscopic methods as well as by comparison of spectral data with those of known related compounds and suggested that the veratryl and guaiacyl groups of these lignans were possibly metabolized preferentially, with oxidation proceeding predominantly through de- O -methylation at the p -position of veratrys.