Mohamed Benhammadi

TL;DR: The authors validated the immunogenicity and efficacy of TSA vaccination for select antigens in mouse models of cancer and demonstrated that the strength of antitumor responses after TSA vaccination was influenced by two parameters that can be estimated in humans and could serve for TSA prioritization in clinical studies.

TL;DR: It is reported that, because of pGE, mature mTECs synthesize substantially more proteins than other cell types and are exquisitely sensitive to loss of immunoproteasomes (IPs), and IP deficiency causes proteotoxic stress in mTecs and leads to exhaustion of postnatal mT EC progenitors.

TL;DR: It is reported that thymic epithelial cells (TECs), particularly the medullary TECs, constitutively express up to 100-fold more cell surface MHC I proteins than epithelial Cells from the skin, colon, and lung.

TL;DR: It is reported that inhalation of the TLR4 ligand LPS upregulates cell surface MHC I by ∼25-fold on the three subtypes of mouse lung ECs, dependent on Nlrc5, Stat1, and Stat2 and caused by a concerted production of the three IFN families.

TL;DR: The role of codon arrangement in the regulation of MAP presentation is demonstrated and integration of both translational and post-translational events in predictive algorithms to ameliorate modeling of the immunopeptidome is supported.