François Major

TL;DR: It is shown how pipelining two computer algorithms based on nucleotide cyclic motifs, MC-Fold and MC-Sym, reproduces a series of experimentally determined RNA three-dimensional structures from the sequence, demonstrating how crucial the consideration of all base-pairing interactions is in filling the gap between sequence and structure.

TL;DR: The results suggest that the autoregulation between E2F1–3 and miR-20a is important for preventing an abnormal accumulation of E 2F1-3 and may play a role in the regulation of cellular proliferation and apoptosis.

TL;DR: This article showed that deletion of the eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) led to an increased ratio of excitatory to inhibitory synaptic inputs and autistic-like behaviors (that is, social interaction deficits, altered communication and repetitive/stereotyped behaviours).

TL;DR: A first, collective, blind experiment in RNA three-dimensional (3D) structure prediction, encompassing three prediction puzzles, to assess the leading edge of RNA structure prediction techniques; compare existing methods and tools; and evaluate their relative strengths, weaknesses, and limitations.

TL;DR: It is demonstrated that Stau1 binds to a complex structure within the ARF1 3′‐UTR, and the efficiency of SMD increases during the differentiation of C2C12 myoblasts to myotubes, and proposed thatStau1 influences the expression of a wide variety of physiologic transcripts and metabolic pathways.