Mohan Somasundaran

TL;DR: It is found that a soluble form of ACE2, but not of the related enzyme ACE1, blocked association of the S1 domain with Vero E6 cells, indicating that ACE2 is a functional receptor for SARS-CoV.

TL;DR: Recently the “Mississippi Child” was reported as having a prolonged clearance of HIV viremia after the initiation of antiretroviral therapy shortly after birth.

TL;DR: It is found that, compared to human ACE2, murine ACE2 less efficiently bound the S1 domain of SARS-CoV and supported less-efficient S protein-mediated infection, which implies that a mouse transgenically expressing humanACE2 may be a useful animal model of Sars.

TL;DR: Human monoclonal antibodies that neutralize SARS-associated coronavirus (SARSCoV) could provide protection for exposed individuals and clinical trials are planned to test MAb 201, a fully human MAb specific for the epitope within the receptor-binding region.

TL;DR: The crystal structure of the catalytically active C-terminal domain was determined and this structure corroborates features previously observed in nuclear magnetic resonance (NMR) studies, a bulge in the second beta strand and a lengthening of the second alpha helix.