Mônica Lopes-Ferreira

TL;DR: This study suggests that independent monitoring programs are needed to quantify the extent of potential impacts caused by the anthropogenic use of the river and to promote the recovery of the impacted area.

TL;DR: A novel family of proteins with kininogenase activity and unique primary structure was characterized using combined pharmacological, proteomic and transcriptomic approaches of Thalassophryne nattereri fish venom, and the complete sequences of natterins did not show any significant similarity with already described tissue kallikreins, Kininogenases or any proteinase.

TL;DR: Venom obtained from fresh captured specimens of this fish was tested in vitro or in animal models for a better characterization of its toxic activities and all venom toxic activities except edema were completely neutralized after in vitro incubation with anti-T.

TL;DR: The myotoxic activity of CB from the three subspecies was lower than the activity of the crotoxin, reinforcing the idea that the fraction CA increases the toxicity of CB.

TL;DR: The results showed striking augments of leukocytes rolling and adherent cells to the endothelium of cremaster mice induced by both venoms, providing in vivo evidence of toxic effects for P. scobina and P. orbignyi venoms.