Showing papers in "Biochimie in 2005"

TL;DR: This review will provide insight on the current understanding of the regulation of insulin signaling in both physiological and pathological conditions through modulations that occur with regards to the functions of the insulin receptor substrate 1 (IRS1).

TL;DR: It appears now that a fine tuning of the MAPKs regulates both normal and pathological adipogenesis, and the precise understanding of the cascade of these molecular events and the way to regulate them will be certainly crucial in order to efficiently fight obesity.

TL;DR: The adipocyte differentiation of hMADS cells has been thoroughly studied and differentiated cells exhibit the unique feature of human adipocytes, and potential applications of stem cells isolated from adipose tissue in medicine will be discussed.

TL;DR: The current view on the role of collagenases in tumor growth, invasion, and metastasis is discussed, as a basis for their feasibility in diagnosis and prognostication, as well as therapeutic targets in cancer patients.

TL;DR: The respective roles of the transcription factor sterol regulatory element binding protein-1c (SREBP- 1c) in mediating the effect of insulin on hepatic gene expression, and the role of carbohydrate responsive element bindingprotein (ChREBP) in regulating gene transcription by glucose are reviewed.

TL;DR: The growing amount of recent clinical data suggests that the impact of gelatinases on treatment decisions should be tested in clinical trials, based on the growing data from recent clinical studies.

TL;DR: The presence and modulation of EMMPRIN in normal tissues associated with increased MMP expression suggests that this EMM PRIN-mediated MMP induction could be a common mechanism in non-tumoral physiological and/or pathological situations.

TL;DR: This review will focus on the families of bacterial efflux systems conferring drug resistance, and on the EPIs that have been identified to restore antibiotic activity.

TL;DR: This work has shown that phosphorylation of perilipin A is essential for HSL translocation and stimulated lipolysis, and this droplet is coated with perilIPin A, which is also phosphorylated by PKA in response to lipolytic stimuli.

TL;DR: It is argued here that evolution of the RNA world taken place in a framework of competing cells and viruses (preys, predators and symbionts) and the hypothesis that viruses played a critical role in the emergence of DNA is expanded.

TL;DR: Findings indicate that AMPK has a pivotal role in regulating pathways that control both energy expenditure and energy intake.

TL;DR: Recently, aptamers have been selected against whole living cells, opening a new avenue which presents three major advantages: direct selection without prior purification of the targets; conservation of membrane proteins in their native conformation similar to the in vivo conditions and identification of (new) targets for a specific phenotype.

TL;DR: MMP structures may contribute significantly to the development of specific MMP inhibitors, which should allow precise control of individual members of the MMP family without affecting all members or the closely related metalloproteinases such as ADAMs and ADAMTSs.

TL;DR: In this paper, the physiological relevance of PPAR phosphorylation is discussed, including changes in ligand affinity, DNA binding, recruitment of transcriptional cofactors, proteasome degradation.

TL;DR: New insights are evaluated into the interplay of MMPs and their molecular partners in melanoma progression and the role of stroma-derived proteases is evaluated.

TL;DR: The role of hyperleptinemia, it is suggested, is to extend survival during famine by permitting the storage of surplus calories in adipocytes without concomitant injury to nonadipose tissues from ectopic lipid deposits.

TL;DR: Light is shed on the new functions of MT-MMPs and their inhibitors in tumor development and angiogenesis, and recent investigations that document their influence on various cell functions are presented.

TL;DR: The DNA structure checkpoints which act within S phase respond to different RFBs in different ways and the processes that are controlled by the DNA replication checkpoints are discussed, paying particular attention to the function of the intra-S phase checkpoint that stabilises the stalled fork.

TL;DR: Great progress has been made over the past decade in elucidating the biology of PPARγ and its role in adipogenesis and glucose metabolism and prospects for future research leading to new therapies for obesity and diabetes are discussed.

TL;DR: A large number of nucleosome assembly factors and regulatory mechanisms collectively function to coordinate the rates of histone and DNA synthesis during both normal cell cycle progression and in response to conditions that interfere with DNA replication.

TL;DR: The activity of matrikines derived from elastin and interstitial or basement membrane collagens on the regulation of matrix metalloproteinases expression and/or activation, and on the plasminogen/plasmin system is summarized.

TL;DR: The most important and well characterized mechanisms involved in the progression of tumor cells through tissues, especially those participating in cellular communication, cell adhesion, and proteolysis are reviewed.

TL;DR: The characteristics of the APH and ACY 1 enzymes involved in the final release of the free amino acids, which are essential to protein synthesis are focused on.

TL;DR: Due to the flexible nature of MMP active-site, the development of specific MMP inhibitors will need to combine sophisticated theoretical and experimental approaches to decipher in each MMP the specific structural and dynamic features that can be exploited to obtain the desired selectivity.

TL;DR: Measurement of matrix metalloproteinase (MMP) activity often remains a challenge, mainly in complex media, and two sets of methods are currently used, which are described and discussed.

TL;DR: A novel family of proteins with kininogenase activity and unique primary structure was characterized using combined pharmacological, proteomic and transcriptomic approaches of Thalassophryne nattereri fish venom, and the complete sequences of natterins did not show any significant similarity with already described tissue kallikreins, Kininogenases or any proteinase.

TL;DR: Overexpression of PFKFB-4 transcript levels in breast and colon malignant tumors correlates with enhanced expression of PKFB-3, hypoxia-inducible factor (HIF)-1alpha and known HIF-1 dependent genes glucose transporter 1 (Glut1) and vascular endothelial growth factor (VEGF).

TL;DR: The origin of these adverse side effects and putative chronology of events leading to CLA-mediated lipoatrophic syndrome are presented and discussed in this review.

TL;DR: It is considered that the proMMP-9/TIMP-1 balance is of critical importance in early events of tumor progression, and might show promise as diagnostic and prognostic marker of malignancy.

TL;DR: In visceral fat cells of PCOS women catecholamine-induced lipolysis is enhanced which cannot be explained by testosterone, and it is possible that the increased testosterone levels are responsible for these abnormalities in catechlamine signal transduction in subcutaneousfat cells ofPCOS women.