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Xiaofeng Zhu
Researcher at Case Western Reserve University
Publications - 72
Citations - 5616
Xiaofeng Zhu is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Population & Genetic association. The author has an hindex of 36, co-authored 72 publications receiving 5396 citations. Previous affiliations of Xiaofeng Zhu include Loyola University Medical Center & University of Pennsylvania.
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Journal ArticleDOI
A common genetic variant is associated with adult and childhood obesity.
Alan Herbert,Norman P. Gerry,Matthew B. McQueen,I. M. Heid,Arne Pfeufer,Thomas Illig,H.-Erich Wichmann,H.-Erich Wichmann,Thomas Meitinger,David J. Hunter,David J. Hunter,Frank B. Hu,Frank B. Hu,Graham A. Colditz,Anke Hinney,Johannes Hebebrand,Kerstin Koberwitz,Kerstin Koberwitz,Xiaofeng Zhu,Richard S. Cooper,Kristin G. Ardlie,Helen N. Lyon,Helen N. Lyon,Helen N. Lyon,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Nan M. Laird,Marc E. Lenburg,Christoph Lange,Christoph Lange,Michael F. Christman +31 more
TL;DR: A dense whole-genome scan of DNA samples from the Framingham Heart Study participants was used to identify a common genetic variant near the INSIG2 gene associated with obesity, suggesting that common genetic polymorphisms are important determinants of obesity.
Journal ArticleDOI
Genetic Structure, Self-Identified Race/Ethnicity, and Confounding in Case-Control Association Studies
Hua Tang,Thomas Quertermous,Beatriz L. Rodriguez,Sharon L.R. Kardia,Xiaofeng Zhu,Andrew Brown,James S. Pankow,Michael A. Province,Steven C. Hunt,Eric Boerwinkle,Nicholas J. Schork,Neil Risch,Neil Risch +12 more
TL;DR: Ancient geographic ancestry, which is highly correlated with self-identified race/ethnicity--as opposed to current residence--is the major determinant of genetic structure in the U.S. population.
Journal ArticleDOI
Reconstructing Genetic Ancestry Blocks in Admixed Individuals
TL;DR: The Markov-hidden Markov model (MHMM) makes it possible to identify genomic blocks of a particular ancestry by use of any high-density single-nucleotide-polymorphism panel, and one application of the method is to perform admixture mapping without genotyping special ancestry-informative-marker panels.
Journal ArticleDOI
Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits
Jacqueline M. Lane,Jingjing Liang,Irma Vlasac,Irma Vlasac,Simon G. Anderson,Simon G. Anderson,David A. Bechtold,Jack Bowden,Richard Emsley,Shubhroz Gill,Max A. Little,Annemarie I. Luik,Andrew S. I. Loudon,Frank A.J.L. Scheer,Shaun Purcell,Shaun Purcell,Shaun Purcell,Simon D. Kyle,Debbie A Lawlor,Xiaofeng Zhu,Susan Redline,David W. Ray,Martin K. Rutter,Martin K. Rutter,Richa Saxena +24 more
TL;DR: In this paper, single and multiple-trait genome-wide association analyses of self-reported sleep duration, insomnia symptoms and excessive daytime sleepiness in the UK Biobank (n = 112,586) were performed.
Journal ArticleDOI
Admixture mapping for hypertension loci with genome-scan markers.
Xiaofeng Zhu,Amy Luke,Richard S. Cooper,Thomas Quertermous,Craig L. Hanis,Thomas H. Mosley,C. Charles Gu,Hua Tang,Dabeeru C. Rao,Neil Risch,Neil Risch,Alan B. Weder +11 more
TL;DR: Admirixture mapping using genome-scan microsatellite markers among the African American participants in the US National Heart, Lung, and Blood Institute's Family Blood Pressure Program suggests that chromosome 6q24 and 21q21 may contain genes influencing risk of hypertension in African Americans.