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Nada Y. Kalaany
Researcher at Boston Children's Hospital
Publications - 20
Citations - 4804
Nada Y. Kalaany is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Cancer & PI3K/AKT/mTOR pathway. The author has an hindex of 12, co-authored 17 publications receiving 4178 citations. Previous affiliations of Nada Y. Kalaany include Harvard University & American University of Beirut.
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Journal ArticleDOI
Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1
David A. Guertin,David A. Guertin,Deanna Stevens,Carson C. Thoreen,Aurora A. Burds,Nada Y. Kalaany,Jason Moffat,Jason Moffat,Michael S. Brown,Kevin Fitzgerald,David M. Sabatini,David M. Sabatini +11 more
TL;DR: MTORC1 function is essential in early development, mLST8 is required only for mTORC2 signaling, and m TORC2 is a necessary component of the Akt-FOXO and PKCalpha pathways.
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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
Richard Possemato,Kevin Marks,Yoav D. Shaul,Michael E. Pacold,Dohoon Kim,Kıvanç Birsoy,Shalini Sethumadhavan,Hin-Koon Woo,Hyun Gyung Jang,Abhishek K. Jha,Walter W. Chen,Francesca G. Barrett,Nicolas Stransky,Zhi-Yang Tsun,Glenn S. Cowley,Jordi Barretina,Jordi Barretina,Nada Y. Kalaany,Peggy P. Hsu,Kathleen Ottina,Albert M. Chan,Bingbing Yuan,Levi A. Garraway,Levi A. Garraway,David E. Root,Mari Mino-Kenudson,Elena F. Brachtel,Edward M. Driggers,David M. Sabatini +28 more
TL;DR: Results reveal that certain breast cancers are dependent upon increased serine pathway flux caused by PHGDH overexpression and demonstrate the utility of in vivo negative-selection RNAi screens for finding potential anticancer targets.
Journal ArticleDOI
LXRS AND FXR: The Yin and Yang of Cholesterol and Fat Metabolism
TL;DR: The elegant, dual interplay between these two receptor systems suggests that they coevolved to constitute a highly sensitive and efficient system for the maintenance of total body fat and cholesterol homeostasis.
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Autophagy is Required for Glucose Homeostasis and Lung Tumor Maintenance
Gizem Karsli-Uzunbas,Jessie Yanxiang Guo,Sandy M. Price,Xin Teng,Saurabh V. Laddha,Sinan Khor,Nada Y. Kalaany,Tyler Jacks,Chang S. Chan,Joshua D. Rabinowitz,Eileen White +10 more
TL;DR: In this article, the essential autophagy gene, autophagrelated-related-7, Atg7, was conditionally deleted throughout adult mice throughout adult life and they found that systemic ATG7 ablation caused susceptibility to infection and neurodegeneration that limited survival to 2-3 months.
Journal ArticleDOI
Tumours with PI3K activation are resistant to dietary restriction
TL;DR: The PI3K pathway is an important determinant of the sensitivity of tumours to dietary restriction, and activating mutations in the pathway may influence the response of cancers to Dietary restriction-mimetic therapies.