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Wenqing Li
Researcher at National Institutes of Health
Publications - 46
Citations - 1935
Wenqing Li is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 15, co-authored 29 publications receiving 1649 citations. Previous affiliations of Wenqing Li include University of Maryland, College Park & National Cancer Research Institute.
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Journal ArticleDOI
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia.
Priscila Pini Zenatti,Daniel Dias Ribeiro,Wenqing Li,Linda Zuurbier,Milene Costa da Silva,Maddalena Paganin,Julia Tritapoe,Julie A. Hixon,André B. Silveira,Bruno A. Cardoso,Leonor M. Sarmento,Nádia C. Correia,María L. Toribio,Joerg Kobarg,Martin A. Horstmann,Rob Pieters,Silvia Regina Brandalise,Adolfo A. Ferrando,Jules P.P. Meijerink,Scott K. Durum,J. Andrés Yunes,João T. Barata +21 more
TL;DR: The findings indicate that IL7R mutational activation is involved in human T-cell leukemogenesis, paving the way for therapeutic targeting of IL-7R–mediated signaling in T-ALL.
Journal ArticleDOI
Cell biology of IL-7, a key lymphotrophin
Qiong Jiang,Wenqing Li,Francesca B. Aiello,Renata Mazzucchelli,Benyam Asefa,Annette R. Khaled,Scott K. Durum +6 more
TL;DR: There remain significant questions regarding IL-7 production and the major producing cells have yet to be fully characterized.
Journal ArticleDOI
Distinct Regions of the Interleukin-7 Receptor Regulate Different Bcl2 Family Members
Qiong Jiang,Wenqing Li,Robert Hofmeister,Howard A. Young,David R. Hodge,Jonathan R. Keller,Annette R. Khaled,Scott K. Durum +7 more
TL;DR: The IL-7 receptor controls at least two distinct pathways, in addition to Stat5, that are required for cell survival, which suggests a sequential model in which Jak1, which binds to Box1, is first activated and then phosphorylates Y449, leading to Bcl2 and Bax regulation, accounting for approximately 90% of the survival function.
Journal ArticleDOI
Oral delivery of IL-27 recombinant bacteria attenuates immune colitis in mice.
Miranda L. Hanson,Julie A. Hixon,Wenqing Li,Barbara K. Felber,Miriam R. Anver,C. Andrew Stewart,Brian M. Janelsins,Sandip K. Datta,Wei Shen,Mairi H. McLean,Scott K. Durum +10 more
TL;DR: Mucosal delivery of the immunosuppressive cytokine interleukin (IL)-27, synthesized actively in situ by the food-grade bacterium L lactis, could be a more effective and safer therapy for inflammatory bowel disease.
Journal ArticleDOI
Development of regulatory T cells requires IL-7Rα stimulation by IL-7 or TSLP
Renata Mazzucchelli,Julie A. Hixon,Rosanne Spolski,Xin Chen,Wenqing Li,Veronica L. Hall,Jami Willette-Brown,Arthur A. Hurwitz,Warren J. Leonard,Scott K. Durum +9 more
TL;DR: It is concluded that regulatory T (Treg) cells, like other T cells, require signals from the IL-7 receptor, but unlike otherT cells, do not require IL- 7 itself because of at least partially overlapping actions of IL-8 and TSLP for development of Treg cells.