Nadine Fornelos

TL;DR: In this article, the authors performed metagenomic sequencing of monthly stool samples from 20 IBD patients and 12 controls (266 total samples) and identified strain-specific functional correlates with IBD outcomes.

TL;DR: Genoppi as mentioned in this paper is a computational tool for integrating genetics and cell-type-specific proteomics data, which is used to analyze 16 cell type-specific protein interaction datasets of four proteins (BCL2, TDP-43, MDM2, PTEN).

TL;DR: The analyses indicate that human iPSC-derived neurons are a relevant model system for studying the involvement of TDP-43 and BCL2 in amyotrophic lateral sclerosis and suggest that the neuron-specific interactions of these proteins are mediating their genetic involvement in neurodevelopmental and neurodegenerative diseases.

TL;DR: In this paper, a protein-protein interaction network for 13 ASD risk genes in human excitatory neurons derived from iPS cells was built and the network contains many reproducible interactions not reported in the literature and is enriched for transcriptionally perturbed genes observed in layer 2/3 cortical neurons of ASD patients.

TL;DR: This study finds a significantly higher abundance in patients of facultative anaerobes that can tolerate the increased oxidative stress of the IBD gut and suggests that R. gnavus may be an important member of the altered gut community in IBD.