A
April Kim
Researcher at Broad Institute
Publications - 15
Citations - 237
April Kim is an academic researcher from Broad Institute. The author has contributed to research in topics: Psychosis & Schizophrenia. The author has an hindex of 7, co-authored 14 publications receiving 181 citations. Previous affiliations of April Kim include Johns Hopkins University & Boston Children's Hospital.
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Journal ArticleDOI
Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders.
Hoang T. Nguyen,Julien Bryois,April Kim,April Kim,Amanda Dobbyn,Laura M. Huckins,Ana B. Muñoz-Manchado,Douglas M. Ruderfer,Giulio Genovese,Giulio Genovese,Menachem Fromer,Xinyi Xu,Dalila Pinto,Sten Linnarsson,Matthijs Verhage,August B. Smit,Jens Hjerling-Leffler,Joseph D. Buxbaum,Christina M. Hultman,Pamela Sklar,Shaun Purcell,Shaun Purcell,Kasper Lage,Kasper Lage,Xin He,Patrick Sullivan,Patrick Sullivan,Eli A. Stahl,Eli A. Stahl +28 more
TL;DR: A pipeline used in ASD studies is extended and applied to infer rare genetic parameters for SCZ and four NDDs and finds many new DD risk genes, supported by gene set enrichment and PPI network connectivity analyses.
Journal ArticleDOI
GeNets: a unified web platform for network-based genomic analyses.
Taibo Li,April Kim,April Kim,Joseph Rosenbluh,Joseph Rosenbluh,Heiko Horn,Heiko Horn,Liraz Greenfeld,Liraz Greenfeld,David An,Andrew Zimmer,Arthur Liberzon,Jon Bistline,Ted Natoli,Yang Li,Yang Li,Yang Li,Aviad Tsherniak,Rajiv Narayan,Ayshwarya Subramanian,Ted Liefeld,Bang Wong,Dawn A. Thompson,Sarah E. Calvo,Sarah E. Calvo,Steve Carr,Jesse S. Boehm,Jacob D. Jaffe,Jill P. Mesirov,Jill P. Mesirov,Nir Hacohen,Nir Hacohen,Aviv Regev,Aviv Regev,Kasper Lage +34 more
TL;DR: The GeNets web platform can identify the most informative network, as well as execute, store and share network-based analyses of RNA-seq or genomic datasets.
Posted ContentDOI
Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders
Hoang T. Nguyen,Julien Bryois,April Kim,Amanda Dobbyn,Laura M. Huckins,Ana B. Muñoz-Manchado,Douglas M. Ruderfer,Giulio Genovese,Menachem Fromer,Xinyi Xu,Dalila Pinto,Sten Linnarsson,Matthijs Verhage,Guus Smit,Jens Hjerling-Leffler,Joseph D. Buxbaum,Christina M. Hultman,Pamela Sklar,Shaun Purcell,Kasper Lage,Xin He,Patrick F. Sullivan,Eli A. Stahl +22 more
TL;DR: A pipeline used in ASD studies is extended and applied to infer rare genetic parameters for SCZ and four NDDs, and many new DD risk genes are detected, supported by gene set enrichment and PPI network connectivity analyses.
Journal ArticleDOI
Early auditory processing evoked potentials (N100) show a continuum of blunting from clinical high risk to psychosis in a pediatric sample.
Joseph Gonzalez-Heydrich,Joseph Gonzalez-Heydrich,Michelle Bosquet Enlow,Michelle Bosquet Enlow,Eugene J. D'Angelo,Eugene J. D'Angelo,Larry J. Seidman,Larry J. Seidman,Sarah Gumlak,April Kim,Kristen A. Woodberry,Kristen A. Woodberry,Ashley Rober,Sahil Tembulkar,Kelsey Graber,Kyle O'Donnell,Hesham M. Hamoda,Hesham M. Hamoda,Kara Kimball,Alexander Rotenberg,Alexander Rotenberg,Lindsay M. Oberman,Alvaro Pascual-Leone,Alvaro Pascual-Leone,Matcheri S. Keshavan,Matcheri S. Keshavan,Frank H. Duffy,Frank H. Duffy +27 more
TL;DR: Longitudinal assessment of the N100 in CHR children who do and do not develop psychosis will inform whether it predicts transition to psychosis and if its response to treatment predicts symptom change.
Journal ArticleDOI
Overlapping 16p13.11 deletion and gain of copies variations associated with childhood onset psychosis include genes with mechanistic implications for autism associated pathways: Two case reports
Catherine A. Brownstein,Robin J. Kleiman,Elizabeth C. Engle,Meghan C. Towne,Eugene J. D'Angelo,Timothy W. Yu,Alan H. Beggs,Jonathan Picker,Jason M. Fogler,Devon Carroll,Rachel C. O. Schmitt,Robert Wolff,Yiping Shen,Va Lip,Kaya Bilguvar,April Kim,Sahil Tembulkar,Kyle O'Donnell,Joseph Gonzalez-Heydrich +18 more
TL;DR: The genotype and neuropsychiatric abnormalities of patients with CNVs in 16p13.11 that developed psychosis before the age of 7 highlight several overlapping genes that have possible mechanistic relevance to pathways previously implicated in Autism Spectrum Disorders, including the mTOR signaling and the ubiquitin‐proteasome cascades.