Paul C. Blainey

TL;DR: In this paper, the authors provide evidence that local microbiota provoke inflammation associated with lung adenocarcinoma by activating lung resident γδ T cells, and link local microbiota-immune crosstalk to lung tumor development and define key cellular and molecular mediators that may serve as effective targets in lung cancer intervention.

TL;DR: High-speed imaging of single hOgg1 enzyme molecules diffusing along DNA stretched by shear flow indicates that DNA glycosylases locate lesion bases by a massively redundant search in which the enzyme selectively binds 8-oxoguanine under kinetic control.

TL;DR: CRISPR-based nucleic acid detection is used in a platform that can simultaneously detect 169 human-associated viruses in multiple samples, providing scalable, multiplexed pathogen detection aimed at routine surveillance for public health.

TL;DR: In this article, the authors performed metagenomic sequencing of monthly stool samples from 20 IBD patients and 12 controls (266 total samples) and identified strain-specific functional correlates with IBD outcomes.

TL;DR: A multiplexed approach based on flow-stretched DNA is used to monitor the enzymatic digestion of λ-phage DNA by individual bacteriophage λ exonuclease molecules, establishing that the melting of a base from the DNA is the rate-limiting step in the catalytic cycle.