P
Paul R. Sleath
Researcher at Corixa Corporation
Publications - 22
Citations - 2114
Paul R. Sleath is an academic researcher from Corixa Corporation. The author has contributed to research in topics: Antigen & Epitope. The author has an hindex of 11, co-authored 22 publications receiving 2004 citations. Previous affiliations of Paul R. Sleath include GlaxoSmithKline.
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Journal ArticleDOI
Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects
Andrew W. Sylwester,Bridget L. Mitchell,John B. Edgar,Cara Taormina,Christian Pelte,Franziska Ruchti,Paul R. Sleath,Kenneth H. Grabstein,Nancy Ann Hosken,Florian Kern,Jay A. Nelson,Louis J. Picker +11 more
TL;DR: The first glimpse of the total human T cell response to a complex infectious agent is provided and insight into the rules governing immunodominance and cross-reactivity in complex viral infections of humans is provided.
Journal Article
Generation of immunity to the HER-2/neu oncogenic protein in patients with breast and ovarian cancer using a peptide-based vaccine.
TL;DR: It is validates that a similar peptide-based vaccine formulation is effective for inducing T-cell immunity to HER-2/neu protein in humans with breast and ovarian cancer.
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Diversity of the CD8+ T-Cell Response to Herpes Simplex Virus Type 2 Proteins among Persons with Genital Herpes
Nancy Ann Hosken,Patrick Mcgowan,Amalia Meier,David M. Koelle,Paul R. Sleath,Felecia Wagener,Mark Elliott,Ken Grabstein,Christine M. Posavad,Lawrence Corey +9 more
TL;DR: The magnitude and breadth of the response in the infected population were greater than previously appreciated and whether this variability in the CD8+ T-cell response within individuals is associated with the frequency of viral reactivation warrants further study.
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A Multi-Epitope Synthetic Peptide and Recombinant Protein for the Detection of Antibodies to Trypanosoma cruzi in Radioimmunoprecipitation-Confirmed and Consensus-Positive Sera
Raymond L. Houghton,Darin R. Benson,Lisa D. Reynolds,Patricia D. Mcneill,Paul R. Sleath,Michael J. Lodes,Skeiky Yasir A W,David A. Leiby,Roberto Badaró,Steven G. Reed +9 more
TL;DR: These studies show that peptides and recombinants containing multiple repeat epitopes are powerful tools for developing assays for T. cruzi antibody detection and have direct application in blood screening.
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Identification and synthesis of a major conserved antigenic epitope of Trypanosoma cruzi.
TL;DR: A gene sequence encoding an immunodominant protein with a repetitive epitope from the protozoan Trypanosoma cruzi, the causative agent of Chagas disease, was cloned and expressed and present within a high-molecular-weight trypomastigote antigen that appears specific to and conserved among T. cruzi isolates.