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Nancy Ruffing
Researcher at Takeda Pharmaceutical Company
Publications - 7
Citations - 2805
Nancy Ruffing is an academic researcher from Takeda Pharmaceutical Company. The author has contributed to research in topics: Chemokine receptor & Chemokine receptor CCR5. The author has an hindex of 6, co-authored 7 publications receiving 2767 citations. Previous affiliations of Nancy Ruffing include Aaron Diamond AIDS Research Center.
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Journal ArticleDOI
CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5
Lijun Wu,Norma P. Gerard,Richard T. Wyatt,Hyeryun Choe,Cristina Parolin,Nancy Ruffing,Alessândra Borsetti,Angelo A. Cardoso,Elizabeth Desjardin,Walter Newman,Craig Gerard,Joseph Sodroski +11 more
TL;DR: It is suggested that HIV-1 attachment to CD4 creates a high-affinity binding site for CCR-5, leading to membrane fusion and virus entry.
Journal ArticleDOI
CCR5 Levels and Expression Pattern Correlate with Infectability by Macrophage-tropic HIV-1, In Vitro
Lijun Wu,William A. Paxton,Nasim Kassam,Nancy Ruffing,James B. Rottman,Nancy Sullivan,Hyeryun Choe,Joseph Sodroski,Walter Newman,Richard A. Koup,Charles R. Mackay +10 more
TL;DR: Anti-CCR5 mAbs were poor inhibitors of chemokine binding, indicating that HIV-1 and ligands bind to separate, but overlapping regions of CCR5, and demonstrate the feasibility of blocking macrophage-tropic HIV- 1 entry into cells with an anti-CCr5 reagent.
Journal ArticleDOI
Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding.
Lijun Wu,Greg LaRosa,Nasim Kassam,Cynthia J. Gordon,Heidi Heath,Nancy Ruffing,Howard H. Chen,Jason Humblias,Michel Samson,Marc Parmentier,John P. Moore,Charles R. Mackay +11 more
TL;DR: The second extracellular loop of CCR5 is an ideal target site for the development of inhibitors of either chemokine or HIV-1 binding to CCR4, suggesting a complicated pattern of HIV- 1 gp120 binding to different regions of C CR5, but a relatively simple pattern for chemokin binding.
Journal ArticleDOI
A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5.
Michael Farzan,Hyeryun Choe,Luis Vaca,Kathleen A. Martin,Ying Sun,Elizabeth Desjardins,Nancy Ruffing,Lijun Wu,Richard T. Wyatt,Norma P. Gerard,Craig Gerard,Joseph Sodroski +11 more
TL;DR: A small tyrosine-rich region of CCR5 proximal to the N-terminal cysteine that is critical for entry of macrophage- Tropic and dual-tropic variants of HIV-1 is identified and identified as necessary for the physical association of the gp120 envelope glycoprotein with C CR5 and for HIV- 1 infection.
Journal ArticleDOI
Discrete Steps in Binding and Signaling of Interleukin-8 with Its Receptor
TL;DR: The results support a model in which the binding and signaling of IL-8 with its receptor occur in at least two discrete steps involving distinct domains of the receptor, consistent with the notion that discrete conformational changes of the receptors secondary to ligand binding are required to trigger various biological responses.