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Nancy Y. Ip
Researcher at Hong Kong University of Science and Technology
Publications - 390
Citations - 37404
Nancy Y. Ip is an academic researcher from Hong Kong University of Science and Technology. The author has contributed to research in topics: Cyclin-dependent kinase 5 & Neurotrophin. The author has an hindex of 78, co-authored 381 publications receiving 34323 citations. Previous affiliations of Nancy Y. Ip include University of Cambridge & Chinese Academy of Sciences.
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Diarylheptanoids from Rhizomes of Alpinia officinarum Inhibit Aggregation of α-Synuclein.
TL;DR: Two new diarylheptanoids are isolated from the rhizomes of Alpinia officinarum and their structures were elucidated by comprehensive spectroscopic analysis, including high-resolution mass spectrometry, infrared spectroscopy, and one- and two-dimensional nuclear magnetic resonance spectroscology.
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Multi‐Omics‐Based Autophagy‐Related Untypical Subtypes in Patients with Cerebral Amyloid Pathology
Jong-Chan Park,Natalia Barahona-Torres,So-Young Jang,Kin Y. Mok,Haeng Jun Kim,Sun Ho Han,Kwang-Hyun Cho,Xiaopu Zhou,Amy K.Y. Fu,Nancy Y. Ip,Jieun Seo,Murim Choi,Hyobin Jeong,Daehee Hwang,Dong Young Lee,Min Soo Byun,Dahyun Yi,Inhee Mook-Jung,John Hardy +18 more
TL;DR: In‐depth studies showed that these subtypes are associated with longitudinal brain changes and autophagy pathways are main contributors for AD pathogenesis, and this study provides a strategy for precision medicine therapy and drug development for AD using integrative multi‐omics analysis and network modelling.
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Beta-catenin in reverse action.
TL;DR: A new study shows that β-catenin is required in muscle to provide an unknown retrograde signal that is necessary for presynaptic transmitter release.
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Differential regulation of the Cdk5-dependent phosphorylation sites of inhibitor-1 and DARPP-32 by depolarization.
Chan Nguyen,Tomohisa Hosokawa,Mahomi Kuroiwa,Nancy Y. Ip,Akinori Nishi,Shin-ichi Hisanaga,James A. Bibb +6 more
TL;DR: Examination of the mechanism by which NMDA modulates the phosphorylation of protein phosphatase inhibitor‐1 at Ser6 and Ser67 and dopamine‐ and cAMP‐regulated phosphoprotein Mr 32 000 at Thr75 revealed that generalized depolarization, rather than specific activation of NMDA receptors, was sufficient to induce decreases in these Cdk5 sites.