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Nancy Y. Ip
Researcher at Hong Kong University of Science and Technology
Publications - 390
Citations - 37404
Nancy Y. Ip is an academic researcher from Hong Kong University of Science and Technology. The author has contributed to research in topics: Cyclin-dependent kinase 5 & Neurotrophin. The author has an hindex of 78, co-authored 381 publications receiving 34323 citations. Previous affiliations of Nancy Y. Ip include University of Cambridge & Chinese Academy of Sciences.
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PatentDOI
Ciliary neurotrophic factor
Piotr Masiakowski,Vivien Wong,Nikos Panayotatos,Hans Thoenen,Stockli-Rippstein Kurt A,Michael Sendtner,Yoshihiro Arakawa,Patrick Carroll,Rudolf Götz,Georg W. Kreutzberg,Dan Lindholm,Friedrich Lottspeich,Nancy Y. Ip,Mark E. Furth +13 more
TL;DR: In this article, the authors proposed a method for cloning and expression of ciliary neurotrophic factor (CNTF) and provided a means for producing human CNTF utilizing human CCL-encoding nucleic acid sequences.
Journal ArticleDOI
Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF
TL;DR: Reports that acute exposure to neurotrophin-3 (NT-3) or brain-derived neurotrophic factor (BDNF)5, but not nerve growth factor (NGF)6, rapidly potentiates the spontaneous and impulse-evoked synaptic activity of developing neuromuscular synapses in culture provide evidence for the regulation of the function of developing synapses by neurotrophins.
Journal ArticleDOI
CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130
Nancy Y. Ip,Steven H. Nye,Tert G. Boulton,Samuel Davis,Tetsuya Taga,Yanping Li,Susan J. Birren,Kiyoshi Yasukawa,Tadamitus Kishimoto,David J. Anderson,Neil Stahl,George D. Yancopoulos +11 more
TL;DR: The receptor system for CNTF is surprisingly unlike those used by the nerve growth factor family of neurotrophic factors, but is instead related to those usedBy a subclass of hematopoietic cytokines.
Journal ArticleDOI
LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor.
Samuel Davis,Aldrich Thomas H,Neil Stahl,Li Pan,Tetsuya Taga,Tadamitsu Kishimoto,Nancy Y. Ip,George D. Yancopoulos +7 more
TL;DR: The ciliary neurotrophic factor receptor complex is shown here to include the CNTF binding protein (CNTFR alpha) as well as the components of the leukemia inhibitory factor (LIF) receptor, LIFR beta (the LIF binding protein) and gp130 [the signal transducer of interleukin-6 (IL-6)].
Journal ArticleDOI
Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.
Nancy Y. Ip,Carlos F. Ibáñez,Steven H. Nye,Joyce McClain,Pamela F. Jones,David R. Gies,Leonardo Belluscio,M M Le Beau,R. Espinosa,Stephen P. Squinto +9 more
TL;DR: A neurotrophin is isolated from both human and rat genomic DNA that appears to represent the mammalian counterpart of Xenopus/viper NT-4, which has many unusual features compared to the previously identified neurotrophins and is less conserved evolutionarily than the other neurotrophs.