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Nancy Y. Ip
Researcher at Hong Kong University of Science and Technology
Publications - 390
Citations - 37404
Nancy Y. Ip is an academic researcher from Hong Kong University of Science and Technology. The author has contributed to research in topics: Cyclin-dependent kinase 5 & Neurotrophin. The author has an hindex of 78, co-authored 381 publications receiving 34323 citations. Previous affiliations of Nancy Y. Ip include University of Cambridge & Chinese Academy of Sciences.
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Overlapping and Distinct Actions of the Neurotrophins BDNF, NT-3, and NT-4/5 on Cultured Dopaminergic and GABAergic Neurons of the Ventral Mesencephalon
TL;DR: BDNF and NT-3 have broadly similar effects in promoting the survival and differentiated phenotype of both dopaminergic and GABAergic neurons of the developing substantia nigra, and it is evident that these two neurotrophins have distinct as well as overlapping actions toward mesencephalic dopaminaergic or GABAergic neuron actions.
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Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth
Thomas M. DeChiara,Richard Vejsada,William Poueymirou,Ann Acheson,Chitra Suri,Joanne C. Conover,Beth Friedman,Joyce McClain,Li Pan,Neil Stahl,Nancy Y. Ip,Ann Kato,George D. Yancopoulos +12 more
TL;DR: Ciliary neurotrophic factor (CNTF) supports motor neuron survival in vitro and in mouse models of motor neuron degeneration and was considered a candidate for the muscle-derived neurotrophic activity that regulates motor neurons survival during development.
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Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses
Samuel Davis,Aldrich Thomas H,Nancy Y. Ip,Neil Stahl,Steven S. Scherer,Thomas Farruggella,Peter S. DiStefano,Rory A. J. Curtis,Nikos Panayotatos,Hugues Gascan,Sylvie Chevalier,George D. Yancopoulos +11 more
TL;DR: These findings not only demonstrate that the CNTF receptor alpha chain is a required component of the functionalCNTF receptor complex but also reveal that it can function in soluble form as part of a heterodimeric ligand.
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Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF
TL;DR: The results suggest that several of the neurotrophins have important effects in the differentiation and maintenance of function of subpopulations of hippocampal neurons.
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Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivo
Beth Friedman,Steven S. Scherer,John S. Rudge,Maureen E. Helgren,Donna Morrisey,Joyce McClain,Da-yuan Wang,Stanley J. Wiegand,Mark E. Furth,Ronald M. Lindsay,Nancy Y. Ip +10 more
TL;DR: It is concluded that the expression of CNTF in Schwann cells depends on axon-Schwann cell interactions, which is similar to the pattern of myelin gene expression in these nerves.