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Nancy Y. Ip
Researcher at Hong Kong University of Science and Technology
Publications - 390
Citations - 37404
Nancy Y. Ip is an academic researcher from Hong Kong University of Science and Technology. The author has contributed to research in topics: Cyclin-dependent kinase 5 & Neurotrophin. The author has an hindex of 78, co-authored 381 publications receiving 34323 citations. Previous affiliations of Nancy Y. Ip include University of Cambridge & Chinese Academy of Sciences.
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Journal ArticleDOI
Systems-level comparison of host-responses elicited by avian H5N1 and seasonal H1N1 influenza viruses in primary human macrophages.
Suki M. Y. Lee,Jennifer L. Gardy,CY Cheung,Timothy K. W. Cheung,Kenrie P Y Hui,Nancy Y. Ip,Yi Guan,Robert E. W. Hancock,J. S. Malik Peiris +8 more
TL;DR: A network-based analysis suggests that the synergy between IFN-β and TNF-α results in an enhanced and sustained IFN and pro-inflammatory cytokine response at the early stage of viral infection that may contribute to the viral pathogenesis and this is of relevance to the design of novel therapeutic strategies for H5N1 induced respiratory disease.
Journal ArticleDOI
Ciliary neurotrophic factor and its receptor complex.
TL;DR: This review focuses on the biological actions of CNTF, the shared and unique features of the CNTF receptor complex and signaling pathways, and the distribution ofCNTF and its receptor during development, in the adult and in response to injury.
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Ganoderma extract activates MAP kinases and induces the neuronal differentiation of rat pheochromocytoma PC12 cells.
TL;DR: The data present the first evidence of the presence of neuroactive compounds that mediate the neuronal differentiation and neuroprotection of the PC12 cells, but also reveal the potential signaling molecules involved in its action.
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Hyperinduction of Cyclooxygenase-2-Mediated Proinflammatory Cascade: A Mechanism for the Pathogenesis of Avian Influenza H5N1 Infection
Suki M. Y. Lee,CY Cheung,John M. Nicholls,Kenrie P Y Hui,Connie Y. H. Leung,Mongkol Uiprasertkul,George L. Tipoe,Yu-Lung Lau,Leo L.M. Poon,Nancy Y. Ip,Yi Guan,J. S. Malik Peiris +11 more
TL;DR: It is revealed that cyclooxygenase-2 (COX-2) was strongly induced in H5N1-infected macrophages in vitro and in epithelial cells of lung tissue samples obtained during autopsy of patients who died of H5n1 disease.
Journal ArticleDOI
Tyk2/STAT3 Signaling Mediates β-Amyloid-Induced Neuronal Cell Death: Implications in Alzheimer's Disease
Jun Wan,Amy K.Y. Fu,Fanny C.F. Ip,Ho Keung Ng,Jacques Hugon,Guylène Page,Jerry H. Wang,Kwok On Lai,Zhenguo Wu,Nancy Y. Ip +9 more
TL;DR: The involvement of the transcription factor signal transducer and activator of transcription 3 (STAT3) in mediating Aβ-induced neuronal death and the potential involvement of Tyk2/STAT3 signaling in AD pathophysiology are reported.