N
Naoto T. Ueno
Researcher at University of Texas MD Anderson Cancer Center
Publications - 390
Citations - 13778
Naoto T. Ueno is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Breast cancer & Inflammatory breast cancer. The author has an hindex of 59, co-authored 389 publications receiving 11623 citations. Previous affiliations of Naoto T. Ueno include University of Texas Health Science Center at Houston & The Breast Cancer Research Foundation.
Papers
More filters
Journal ArticleDOI
Challenges and perspective of drug repurposing strategies in early phase clinical trials.
Shumei Kato,Stacy L. Moulder,Naoto T. Ueno,Jennifer J. Wheler,Funda Meric-Bernstam,Razelle Kurzrock,Filip Janku +6 more
TL;DR: This review delineates the experience and challenges with drug repurposing strategies at MD Anderson Cancer Center, which demonstrated promising outcomes in patients with both rare and common treatment refractory advanced cancers.
Journal ArticleDOI
PEA-15 inhibits tumorigenesis in an MDA-MB-468 triple-negative breast cancer xenograft model through increased cytoplasmic localization of activated extracellular signal-regulated kinase.
Chandra Bartholomeusz,Ana M. Gonzalez-Angulo,Anna Kazansky,Savitri Krishnamurthy,Ping Liu,Linda X. H. Yuan,Fumiyuki Yamasaki,Shuying Liu,Naoki Hayashi,Dongwei Zhang,Francisco J. Esteva,Gabriel N. Hortobagyi,Naoto T. Ueno +12 more
TL;DR: Overexpression of PEA-15 in breast cancer cells resulted in growth inhibition, reduction in DNA synthesis, and onset of caspase-8–dependent apoptosis, and PEAA-15 has therapeutic potential in breast cancers.
Journal ArticleDOI
Epidemiological risk factors associated with inflammatory breast cancer subtypes
Rachel L. Atkinson,Randa El-Zein,Randa El-Zein,Vicente Valero,Anthony Lucci,Therese B. Bevers,Tamer M. Fouad,Weiqin Liao,Naoto T. Ueno,Wendy A. Woodward,Wendy A. Woodward,Abenaa M. Brewster +11 more
TL;DR: Modifiable risk factors, age at first pregnancy, breast-feeding, and smoking may be associated with specific IBC subtypes, and the importance of evaluating epidemiologic risk factors for IBC for the identification of subtype-specific prevention strategies is highlighted.
Journal ArticleDOI
Targeting p70S6K Prevented Lung Metastasis in a Breast Cancer Xenograft Model
Ugur Akar,Bulent Ozpolat,Kapil Mehta,Gabriel Lopez-Berestein,Dongwei Zhang,Naoto T. Ueno,Gabriel N. Hortobagyi,Banu Arun +7 more
TL;DR: It is shown that p70S6K plays an important role in metastasis by regulating key proteins like cyclin D1, PDCD4, focal adhesion kinase, E-cadherin, β-catenin, and tissue transglutaminase 2, which are essential for cell attachment, survival, invasion, and metastasis in breast cancer.
Journal ArticleDOI
JNK Signaling in Stem Cell Self-Renewal and Differentiation.
TL;DR: The functions of the JNK signaling pathway in self-renewal and differentiation, which are essential features of various types of stem cells, such as embryonic, induced pluripotent, and adult tissue-specific stem cells are described.