Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties
Galina F. Sud'ina,O. K. Mirzoeva,Marina A. Pushkareva,Galina A. Korshunova,Natalia V. Sumbatyan,Sergei D. Varfolomeev +5 more
TLDR
Caffeic acid phenethyl ester, an active component of propolis extract, inhibits 5‐lipoxygenase in the micromolar concentration range and exhibits antioxidant properties.About:
This article is published in FEBS Letters.The article was published on 1993-08-23 and is currently open access. It has received 471 citations till now. The article focuses on the topics: Caffeic acid phenethyl ester & Caffeic acid.read more
Citations
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Structure-antioxidant activity relationships of flavonoids and phenolic acids
TL;DR: The factors underlying the influence of the different classes of polyphenols in enhancing their resistance to oxidation are discussed and support the contention that the partition coefficients of the flavonoids as well as their rates of reaction with the relevant radicals define the antioxidant activities in the lipophilic phase.
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Antioxidant activities of caffeic acid and its related hydroxycinnamic acid compounds
Jiang Hong Chen,Chi-Tang Ho +1 more
TL;DR: In this paper, the authors compared the antioxidative and free radical scavenging activities of caffeic acid compounds with those of α-tocopherol and BHT in the Rancimat test and found that the addition of test compounds in lard significantly extended the induction time of lipid oxidation.
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Lipid oxidation and improving the oxidative stability.
Fereidoon Shahidi,Ying Zhong +1 more
TL;DR: This tutorial review will provide important knowledge about lipid oxidation, including the mechanism and factors involved in oxidation, as well as strategies for improving oxidative stability of lipids.
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Antimicrobial action of propolis and some of its components: the effects on growth, membrane potential and motility of bacteria
TL;DR: Propolis and some of its cinnamic and flavonoid components were found to uncouple the energy transducing cytoplasmic membrane and to inhibit bacterial motility, which may contribute to the antimicrobial action of propolis and its observed synergism with selected antibiotics.
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Free radical scavenging and antioxidative activity of caffeic acid amide and ester analogues: structure-activity relationship.
S.M. Son,Betty A. Lewis +1 more
TL;DR: The structure-activity relationships of synthetic caffeic acid amide and ester analogues as potential antioxidants and free radical scavengers have been investigated and it is established that hydrophobic antioxidants tend to exhibit better antioxidative activity in an emulsion system.
References
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Recent investigations into the lipoxygenase pathway of plants
TL;DR: The plant lipoxygenase (LOX) pathway is in many respects the equivalent of the 'arachidonic acid cascade' in animals, and hormonal and anti-fungal activities have been reported.
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Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis.
Dezider Grunberger,R. Banerjee,K. Eisinger,Eugene M. Oltz,L. Efros,M. Caldwell,V. Estevez,Koji Nakanishi +7 more
TL;DR: Differential cytotoxicity has been observed in normal rat/human versus transformed rat/ human melanoma and breast carcinoma cell lines in the presence of CAPE, which was readily prepared in one step.
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Caffeic acid is a selective inhibitor for leukotriene biosynthesis
TL;DR: Caffeic acid, which is one of the most common reagents, is a selective inhibitor for 5-lipoxygenase and therefore for leukotriene biosynthesis, and its methyl ester did not inhibit prostaglandin synthase activity at all, but rather stimulate at higher doses.