Nels C. Elde

TL;DR: Recent findings supporting the long-standing hypothesis that the waves of TE invasions endured by organisms for eons have catalysed the evolution of gene-regulatory networks are reviewed.

TL;DR: The T. thermophila genome has been used for functional genomic studies to address biological, biomedical, and biotechnological questions of fundamental importance as mentioned in this paper, and it has been shown that the excision of DNA from the MIC to generate the macronucleus specifically targets foreign DNA as a form of genome self-defense.

TL;DR: It is found that ERVs have shaped the evolution of a transcriptional network underlying the interferon (IFN) response, a major branch of innate immunity, and that lineage-specific ERV have dispersed numerous IFN-inducible enhancers independently in diverse mammalian genomes.

TL;DR: The discovery of viral "gene-accordions" explains how poxviruses can rapidly adapt to defeat different host defenses despite low mutation rates and reveals how classical Red Queen conflicts can progress through unrecognized intermediates.

TL;DR: Host factors such as PKR can compete in molecular ‘arms races’ with mimics because of evolutionary flexibility at protein interaction interfaces challenged by mimicry, uncovering evolutionary strategies by which host proteins can overcome mimicry.