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Walter L. Ruzzo
Researcher at University of Washington
Publications - 121
Citations - 13923
Walter L. Ruzzo is an academic researcher from University of Washington. The author has contributed to research in topics: Gene & RNA. The author has an hindex of 47, co-authored 120 publications receiving 13133 citations. Previous affiliations of Walter L. Ruzzo include J. Craig Venter Institute & Seattle University.
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Journal ArticleDOI
Protection in operating systems
TL;DR: A model of protection mechanisms in computing systems is presented and its appropriateness is argued and it can be shown that this problem is decidable, i.e. there is an algorithm to determine whether a system in a particular configuration is safe.
Journal ArticleDOI
Principal component analysis for clustering gene expression data.
Ka Yee Yeung,Walter L. Ruzzo +1 more
TL;DR: The empirical study showed that clustering with the PCs instead of the original variables does not necessarily improve, and often degrades, cluster quality, and would not recommend PCA before clustering except in special circumstances.
Journal ArticleDOI
Model-based clustering and data transformations for gene expression data.
TL;DR: The model-based approach has superior performance on synthetic data sets, consistently selecting the correct model and the number of clusters, and the validity of the Gaussian mixture assumption on different transformations of real data is explored.
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Macronuclear Genome Sequence of the Ciliate Tetrahymena thermophila, a Model Eukaryote
Jonathan A. Eisen,Robert S. Coyne,Martin Wu,Dongying Wu,Mathangi Thiagarajan,Jennifer R. Wortman,Jonathan H. Badger,Qinghu Ren,Paolo Amedeo,Kristie M. Jones,Luke J. Tallon,Arthur L. Delcher,Steven L. Salzberg,Joana C. Silva,Brian J. Haas,William H. Majoros,Maryam Farzad,Jane M. Carlton,Jane M. Carlton,Roger Smith,Jyoti Garg,Ronald E. Pearlman,Kathleen M Karrer,Lei Sun,Gerard Manning,Nels C. Elde,Aaron P. Turkewitz,David J. Asai,David E. Wilkes,Yufeng Wang,Hong-Hong Cai,Kathleen E Collins,B. Andrew Stewart,Suzanne R. Lee,Katarzyna Wilamowska,Zasha Weinberg,Walter L. Ruzzo,Dorota Wloga,Jacek Gaertig,Joseph Frankel,Che-Chia Tsao,Martin A. Gorovsky,Patrick J. Keeling,Ross F. Waller,Nicola J. Patron,J. Michael Cherry,Nicholas A. Stover,Cynthia J. Krieger,Christina del Toro,Hilary F. Ryder,Sondra Williamson,Rebecca A Barbeau,Eileen P. Hamilton,Eduardo Orias +53 more
TL;DR: The T. thermophila genome has been used for functional genomic studies to address biological, biomedical, and biotechnological questions of fundamental importance as mentioned in this paper, and it has been shown that the excision of DNA from the MIC to generate the macronucleus specifically targets foreign DNA as a form of genome self-defense.
Journal ArticleDOI
Validating clustering for gene expression data
TL;DR: This work provides a systematic framework for assessing the results of clustering algorithms for gene expression data sets by applying a clustering algorithm to the data from all but one experimental condition.