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Aaron P. Turkewitz
Researcher at University of Chicago
Publications - 70
Citations - 2771
Aaron P. Turkewitz is an academic researcher from University of Chicago. The author has contributed to research in topics: Tetrahymena & Exocytosis. The author has an hindex of 27, co-authored 67 publications receiving 2420 citations. Previous affiliations of Aaron P. Turkewitz include University of California, San Francisco & University of Illinois at Chicago.
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Macronuclear Genome Sequence of the Ciliate Tetrahymena thermophila, a Model Eukaryote
Jonathan A. Eisen,Robert S. Coyne,Martin Wu,Dongying Wu,Mathangi Thiagarajan,Jennifer R. Wortman,Jonathan H. Badger,Qinghu Ren,Paolo Amedeo,Kristie M. Jones,Luke J. Tallon,Arthur L. Delcher,Steven L. Salzberg,Joana C. Silva,Brian J. Haas,William H. Majoros,Maryam Farzad,Jane M. Carlton,Jane M. Carlton,Roger Smith,Jyoti Garg,Ronald E. Pearlman,Kathleen M Karrer,Lei Sun,Gerard Manning,Nels C. Elde,Aaron P. Turkewitz,David J. Asai,David E. Wilkes,Yufeng Wang,Hong-Hong Cai,Kathleen E Collins,B. Andrew Stewart,Suzanne R. Lee,Katarzyna Wilamowska,Zasha Weinberg,Walter L. Ruzzo,Dorota Wloga,Jacek Gaertig,Joseph Frankel,Che-Chia Tsao,Martin A. Gorovsky,Patrick J. Keeling,Ross F. Waller,Nicola J. Patron,J. Michael Cherry,Nicholas A. Stover,Cynthia J. Krieger,Christina del Toro,Hilary F. Ryder,Sondra Williamson,Rebecca A Barbeau,Eileen P. Hamilton,Eduardo Orias +53 more
TL;DR: The T. thermophila genome has been used for functional genomic studies to address biological, biomedical, and biotechnological questions of fundamental importance as mentioned in this paper, and it has been shown that the excision of DNA from the MIC to generate the macronucleus specifically targets foreign DNA as a form of genome self-defense.
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Functional genomics: the coming of age for Tetrahymena thermophila.
TL;DR: Tetrahymena thermophila is manipulated to generate a premier experimental organism for functional genomic analysis and the coupling of forward and reverse genetic approaches with genomics-based methods for gene discovery presents a bright future for research in this rising model eukaryote.
Journal ArticleDOI
Evolutionary cell biology: Two origins, one objective
Michael Lynch,Mark C. Field,Holly V. Goodson,Harmit S. Malik,José B. Pereira-Leal,David S. Roos,Aaron P. Turkewitz,Shelley Sazer +7 more
TL;DR: Evolutionary cell biology is defined as the fusion of these two eponymous fields with the theoretical and quantitative branches of biochemistry, biophysics, and population genetics to develop a mechanistic understanding of general evolutionary processes, while specifically infusing cell biology with an evolutionary perspective.
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A high yield purification of the human transferrin receptor and properties of its major extracellular fragment.
TL;DR: A new high yield affinity purification protocol for transferrin receptor from placenta is reported which produces 3-4 mg of highly purified protein.
Journal ArticleDOI
Elucidation of Clathrin-Mediated Endocytosis in Tetrahymena Reveals an Evolutionarily Convergent Recruitment of Dynamin
TL;DR: It is demonstrated that parasomal sacs are sites of clathrin-dependent endocytosis and that AP-2 localizes to these sites, and functional analysis suggests that the precise roles of dynamins in endocyTosis, as well as the mechanisms of targeting, differ in metazoans and ciliates.