Niamh C. Williams

TL;DR: Findings identify citrate as an important metabolite for macrophage and DC effector function and itaconate has a direct antibacterial effect and also has been shown to act as an anti-inflammatory agent, inhibiting succinate dehydrogenase.

TL;DR: It is demonstrated that mice deficient in Irp2 were protected from cigarette smoke (CS)-induced experimental COPD, and mitochondrial iron chelation alleviated CS-induced impairment of MCC, CS- induced pulmonary inflammation and CS-associated lung injury in mice with established COPD.

TL;DR: It is shown that MyD88 adaptor-like (MAL), an adaptor protein in TLR signaling, undergoes glutathionylation in response to LPS, driving macrophage responses to proinflammatory stimuli, and the solution structure of MAL in the reduced form without disulfides is determined, revealing a typical BB loop observed in adaptor proteins, in contrast to previously reported crystal structures.

TL;DR: In this article, the role of ATP citrate lyase (ACLY) in NF-κB acetylation and its full activation in human PBMC-derived macrophages was investigated.

TL;DR: In this paper, the intricate role of nutritional immunity in host immune cells of the lung and how changes in this fundamental process as a result of chronic lung disease may alter the airway microbiome, disease progression and the response to infection.