Nick J. Carroll

TL;DR: P porous nanoparticle-supported lipid bilayers (protocells) that synergistically combine properties of liposomes and nanoporous particles are reported that allow a single protocell loaded with a drug cocktail to kill a drug-resistant HCC cell, representing a 106-fold improvement over comparable liposome.

TL;DR: The ability to predict and program IDP-rich assemblies in this fashion offers new insights into (1) genetic-to-molecular- to-macroscale relationships that encode hierarchical IDP assemblies, (2) design rules of such assemblies in cell biology and (3) molecular-level engineering of self-assembled recombinant IDPs-rich materials.

TL;DR: A novel method for the fabrication of monodisperse mesoporous silica particles is suggested, based on the formation of well-defined equally sized emulsion droplets using a microfluidic approach, to create 2D or 3D structures with hierarchical porosity.

TL;DR: Tuning the degree of membrane fluidity by tailoring the amount of plasticizing stimulus present allows us to obtain temporal variation of the release kinetics from a subsecond abrupt burst release to a slow sustained release of encapsulant over many minutes.