How has Japan become a major economic power, a world leader in the automotive and electronics industries? What is the secret of their success? The consensus has been that, though the Japanese are not particularly innovative, they are exceptionally skilful at imitation, at improving products that already exist. But now two leading Japanese business experts, Ikujiro Nonaka and Hiro Takeuchi, turn this conventional wisdom on its head: Japanese firms are successful, they contend, precisely because they are innovative, because they create new knowledge and use it to produce successful products and technologies. Examining case studies drawn from such firms as Honda, Canon, Matsushita, NEC, 3M, GE, and the U.S. Marines, this book reveals how Japanese companies translate tacit to explicit knowledge and use it to produce new processes, products, and services.

The knowledge-creating company : how Japanese companies create the dynamics of innovation

ing WS1S Systems to Verify Parameterized Networks . . . . . . . . . . . . 188 Kai Baukus, Saddek Bensalem, Yassine Lakhnech and Karsten Stahl FMona: A Tool for Expressing Validation Techniques over Infinite State Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 204 J.-P. Bodeveix and M. Filali Transitive Closures of Regular Relations for Verifying Infinite-State Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 220 Bengt Jonsson and Marcus Nilsson Diagnostic and Test Generation Using Static Analysis to Improve Automatic Test Generation . . . . . . . . . . . . . 235 Marius Bozga, Jean-Claude Fernandez and Lucian Ghirvu Efficient Diagnostic Generation for Boolean Equation Systems . . . . . . . . . . . . 251 Radu Mateescu Efficient Model-Checking Compositional State Space Generation with Partial Order Reductions for Asynchronous Communicating Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 266 Jean-Pierre Krimm and Laurent Mounier Checking for CFFD-Preorder with Tester Processes . . . . . . . . . . . . . . . . . . . . . . . 283 Juhana Helovuo and Antti Valmari Fair Bisimulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 299 Thomas A. Henzinger and Sriram K. Rajamani Integrating Low Level Symmetries into Reachability Analysis . . . . . . . . . . . . . 315 Karsten Schmidt Model-Checking Tools Model Checking Support for the ASM High-Level Language . . . . . . . . . . . . . . 331 Giuseppe Del Castillo and Kirsten Winter Table of

Tools and Algorithms for the Construction and Analysis of Systems. Proc. TACAS 2009

The Martini coarse-grained force field has been successfully used for simulating a wide range of (bio)molecular systems. Recent progress in our ability to test the model against fully atomistic force fields, however, has revealed some shortcomings. Most notable, phenylalanine and proline were too hydrophobic, and dimers formed by polar residues in apolar solvents did not bind strongly enough. Here, we reparametrize these residues either through reassignment of particle types or by introducing embedded charges. The new parameters are tested with respect to partitioning across a lipid bilayer, membrane binding of Wimley–White peptides, and dimerization free energy in solvents of different polarity. In addition, we improve some of the bonded terms in the Martini protein force field that lead to a more realistic length of α-helices and to improved numerical stability for polyalanine and glycine repeats. The new parameter set is denoted Martini version 2.2.

/pdf/improved-parameters-for-the-martini-coarse-grained-protein-4ecsxredvf.pdf

Improved Parameters for the Martini Coarse-Grained Protein Force Field

The Martini model, a coarse-grained force field for biomolecular simulations, has found a broad range of applications since its release a decade ago. Based on a building block principle, the model combines speed and versatility while maintaining chemical specificity. Here we review the current state of the model. We describe recent highlights as well as shortcomings, and our ideas on the further development of the model.

/pdf/perspective-on-the-martini-model-48a9823w5f.pdf

Perspective on the Martini model.

For simulations of membranes and membrane proteins, the generation of the lipid bilayer is a critical step in the setup of the system. Membranes comprising multiple components pose a particular challenge, because the relative abundances need to be controlled and the equilibration of the system may take several microseconds. Here we present a comprehensive method for building membrane containing systems, characterized by simplicity and versatility. The program uses preset, coarse-grain lipid templates to build the membrane, and also allows on-the-fly generation of simple lipid types by specifying the headgroup, linker, and lipid tails on the command line. The resulting models can be equilibrated, after which a relaxed atomistic model can be obtained by reverse transformation. For multicomponent membranes, this provides an efficient means for generating equilibrated atomistic models. The method is called insane, an acronym for INSert membrANE. The program has been made available, together with the complemen...

Computational Lipidomics with insane: A Versatile Tool for Generating Custom Membranes for Molecular Simulations

Internet of Things and Health Care in Pandemic COVID-19: System Requirements Evaluation

Working in the coronavirus COVID-19 pandemic context, the entire world has started to perform their activities in online medium. This current situation has affected multiple industries and made companies realize the need of digitalization of a number vital but time-consuming processes. They are presently found in all activity domains when talking about paperwork and communication between governments and educational institutions. The article is based on the idea that as automation is gaining more and more access into our everyday lives, the old school methods of storing information will soon be replaced by databases of enormous dimensions which can be managed by people. Also, the technology available now, has the methods of helping the bureaucratic processes having as an effect a better communication between citizens and government. The paper presents a different perspective on how the documents can be archived and transmitted. It exposes the architecture of a system that has more features than common document management systems.

G-Cloud Briefcase - Electronic Archive for Academic Certificates and General Certificates of Education Documents Using Public Private Hyperspace for E-Government Library Services Based on NOSQL Databases

This article presents the parallel implementation of a new multiscale model that is currently developed in the Molecular Dynamics Group from the University of Groningen. Multiscale methods combine the advantages of two levels of simulation, an atomistic and a coarse-grain one, with a small loss of performance. We designed a parallel implementation of this multiscale approach based on the improved parallel algorithms from the GROMACS MD simulator. The properties of the simulated systems were undisturbed and the errors were kept to a minimum. By having a parallel multiscale simulation, one can take advantage of a reduced simulation time by running it on multiple processors, and in the same time, access to both atomistic and macroscopic details is offered for a better understanding of the desired phenomenon.

Multiscaling algorithms for molecular dynamics simulations with GROMACS

When it is tried to control drones, there are many different ways through various devices, using either motions like facial motion, special gloves with sensors, red, green, blue cameras on the laptop or even using smartwatches by performing gestures that are picked up by motion sensors. The paper proposes a work on how drones could be controlled using brainwaves without any of those devices. The drone control system of the current research was developed using electroencephalogram signals took by an Emotiv Insight headset. The electroencephalogram signals are collected from the users brain. The processed signal is then sent to the computer via Bluetooth. The headset employs Bluetooth Low Energy for wireless transmission. The brain of the user is trained in order to use the generated electroencephalogram data. The final signal is transmitted to Raspberry Pi zero via the MQTT messaging protocol. The Raspberry Pi controls the movement of the drone through the incoming signal from the headset. After years, brain control can replace many normal input sources like keyboards, touch screens or other traditional ways, so it enhances interactive experiences and provides new ways for disabled people to engage with their surroundings.

Drone Control based on Mental Commands and Facial Expressions

Electronic healthcare devices are considerably more utilized as the time passes. Pregnant women who suffer from preeclampsia and the persons who have cardiac diseases can have their heart rate monitored through the use of a smart bracelet. The created bracelet sends the measured values towards the user's associated smart phone and then to the system's server. The server interprets the health parameters and alerts the associated relatives, caregivers and the doctor in case of an emergency by sending an SMS. On the system's forum the bracelet's user can write about the current health symptoms and the medical experience. Sentiment analysis is applied to determine if a critical situation has been described. In this case, an SMS alert is delivered to the user's doctor. This close connection between the patient and doctor upgrades the quality of life.

Nicolae Goga

Papers

Internet of Things and Health Care in Pandemic COVID-19: System Requirements Evaluation

G-Cloud Briefcase - Electronic Archive for Academic Certificates and General Certificates of Education Documents Using Public Private Hyperspace for E-Government Library Services Based on NOSQL Databases

Multiscaling algorithms for molecular dynamics simulations with GROMACS

Drone Control based on Mental Commands and Facial Expressions

Healthcare System Based on the Smart Monitoring Bracelets and Sentiment Analysis