P
Paul Brown
Researcher at National Institutes of Health
Publications - 253
Citations - 13704
Paul Brown is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Bovine spongiform encephalopathy & Scrapie. The author has an hindex of 59, co-authored 251 publications receiving 13251 citations. Previous affiliations of Paul Brown include Walter and Eliza Hall Institute of Medical Research & Research Triangle Park.
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Journal ArticleDOI
Classification of sporadic Creutzfeldt‐Jakob disease based on molecular and phenotypic analysis of 300 subjects
Piero Parchi,Armin Giese,Sabina Capellari,Paul Brown,Walter J. Schulz-Schaeffer,Otto Windl,Inga Zerr,Herbert Budka,Nicolas Kopp,Pedro Piccardo,Sigrid Poser,Amyn M. Rojiani,Nathalie Streichemberger,Jean Julien,Claude Vital,Bernardino Ghetti,Pierluigi Gambetti,Hans A. Kretzschmar +17 more
TL;DR: The present data demonstrate the existence of six phenotypic variants of sCJD, and the physicochemical properties of PrPSc in conjunction with the PRNP codon 129 genotype largely determine this phenotypesic variability, and allow a molecular classification of the disease variants.
Journal ArticleDOI
Fatal familial insomnia and familial Creutzfeldt-Jakob disease: disease phenotype determined by a DNA polymorphism
Lev G. Goldfarb,Robert B. Petersen,Massimo Tabaton,Paul Brown,Andréa C. LeBlanc,Pasquale Montagna,Pietro Cortelli,Jean Julien,Claude Vital,William W. Pendelbury,Matii Haltia,Peter R. Wills,Jean J. Hauw,Paul E. McKeever,L. Monari,Bertold Schrank,Gary D. Swergold,Lucila Autilio-Gambetti,D. Carleton Gajdusek,Elio Lugaresi,Pierluigi Gambetti +20 more
TL;DR: Two distinct disease phenotypes linked to a single pathogenic mutation can be determined by a common polymorphism.
Journal ArticleDOI
B lymphocytes and neuroinvasion.
TL;DR: Studies of the brain, spleen and marrow of many immunodeficient mouse lines indicate that differentiated B lymphocytes are important for neuroinvasion, which has implications for therapies against CJD, and also for the broader public-health issue of screening blood products against possible infection.
Journal ArticleDOI
Neuropathological Diagnostic-criteria for Creutzfeldt-jakob-disease (cjd) and Other Human Spongiform Encephalopathies (prion Diseases)
Herbert Budka,Adriano Aguzzi,Paul Brown,Jean-Marie Brucher,Orso Bugiani,Filippo Gullotta,Matti Haltia,Jean-Jacques Hauw,James W. Ironside,Kurt A. Jellinger,Hans A. Kretzschmar,Peter L. Lantos,Carlo Masullo,Wolfgang Schlote,Jun Tateishi,Roy O. Weller +15 more
TL;DR: Neuropathological diagnostic criteria for Creutzfeldt‐Jakob disease (CJD) and other human transmissible spongiform encephalopathies (prion diseases) are proposed.
Journal ArticleDOI
The distribution of infectivity in blood components and plasma derivatives in experimental models of transmissible spongiform encephalopathy
TL;DR: The administration of blood components from donors who subsequently develop Creutzfeldt‐Jakob disease has raised the issue of blood as a possible vehicle for iatrogenic disease.