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Nicole Salès
Researcher at Scripps Research Institute
Publications - 13
Citations - 1410
Nicole Salès is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Bovine spongiform encephalopathy & Scrapie. The author has an hindex of 11, co-authored 13 publications receiving 1333 citations. Previous affiliations of Nicole Salès include University of Caen Lower Normandy & French Alternative Energies and Atomic Energy Commission.
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Journal ArticleDOI
MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction
Jannet Kocerha,Mohammad Ali Faghihi,Miguel A. Lopez-Toledano,Jia Huang,Jia Huang,Amy J. Ramsey,Marc G. Caron,Nicole Salès,David Willoughby,Joacim Elmén,Henrik Frydenlund Hansen,Henrik Ørum,Sakari Kauppinen,Sakari Kauppinen,Paul J. Kenny,Claes Wahlestedt +15 more
TL;DR: In vivo inhibition of miR-219 by specific antimiR in the murine brain significantly modulated behavioral responses associated with disrupted NMDA receptor transmission, and pretreatment with the antipsychotic drugs haloperidol and clozapine prevented dizocilpine-induced effects on miR -219.
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In Vitro and In Vivo Neurotoxicity of Prion Protein Oligomers
Steve Simoneau,Human Rezaei,Nicole Salès,Gunnar Kaiser-Schulz,Maxime Lefebvre-Roque,Maxime Lefebvre-Roque,Catherine Vidal,Jean Guy Fournier,Julien Comte,Franziska Wopfner,Jeanne Grosclaude,Hermann M. Schätzl,Corinne Ida Lasmézas +12 more
TL;DR: The identification of toxic PrP species in vivo shows that PrP-induced neurodegeneration shares common mechanisms with other brain amyloidoses like Alzheimer disease and opens new avenues for neuroprotective intervention strategies of prion diseases targeting PrP oligomers.
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Evaluation of Quinacrine Treatment for Prion Diseases
Agnès Barret,Fabrizio Tagliavini,Gianluigi Forloni,Clive Bate,Mario Salmona,Laura Colombo,A. De Luigi,Lucia Limido,Silvia Suardi,Giacomina Rossi,Frédéric Auvré,Karim Tarik Adjou,Nicole Salès,Alun Williams,Corinne Ida Lasmézas,Jean-Philippe Deslys +15 more
TL;DR: Despite its ability to cross the blood-brain barrier, the use of quinacrine for the treatment of CJD is questionable, at least as a monotherapy, and the multistep experimental approach employed here could be used to test new therapeutic regimes before their use in human trials.
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Tissue distribution of bovine spongiform encephalopathy agent in primates after intravenous or oral infection
Christian Herzog,Nicole Salès,Etchegaray N,Aurore Charbonnier,Sophie Freire,Dominique Dormont,Jean-Philippe Deslys,Corinne Ida Lasmézas +7 more
TL;DR: The findings suggest that the possible risk of vCJD linked to endoscopic procedures might be currently underestimated and humans infected intravenously with variant Creutzfeldt-Jakob disease need the same precautionary measures with respect to blood and tissue donations and surgical procedures.
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Atypical BSE (BASE) transmitted from asymptomatic aging cattle to a primate.
Emmanuel Comoy,Cristina Casalone,Nathalie Lescoutra-Etchegaray,Gianluigi Zanusso,Sophie Freire,Dominique Marcé,Frédéric Auvré,Marie-Magdeleine Ruchoux,Sergio Ferrari,Salvatore Monaco,Nicole Salès,Maria Caramelli,Philippe Leboulch,Paul Brown,Corinne Ida Lasmézas,Jean-Philippe Deslys +15 more
TL;DR: Despite the waning epidemic of classical BSE, the occurrence of atypical strains should temper the urge to relax measures currently in place to protect public health from accidental contamination by BSE-contaminated products.