Daniel L. Crimmins

TL;DR: Neurogranin is a promising biomarker for AD because levels were elevated in patients with AD compared with cognitively normal participants and predicted progression from MCI to AD, and within-person levels of NGRN increased in cognitivelynormal participants but not in Patients with later stage MCI or AD, which suggests that N GRN may reflect presymptomatic synaptic dysfunction or loss.

TL;DR: The Clinical Proteomic Tumor Analysis Consortium of the National Cancer Institute has collaborated with clinical laboratorians, peptide manufacturers, metrologists, representatives of the pharmaceutical industry, and other professionals to develop a consensus set of recommendations for peptide procurement, characterization, storage, and handling.

TL;DR: It is hypothesized that one mechanism underlying the association between obstructive sleep apnea (OSA) and Alzheimer's disease is OSA leading to decreased slow wave activity (SWA), increased synaptic activity, decreased glymphatic clearance, and increased amyloid‐β.

TL;DR: Results indicate that, for the C5 convertases, decay accelerating activity is mediated primarily by site 1, and a properly spaced site 2 has an important auxiliary role, which may involve its C3b binding capacity.

TL;DR: A simple method to obtain internal amino acid sequences from larger proteins electroblotted to polyvinyldifluoride membranes and subjected to gas-phase microsequence analysis is reported.