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Niklaus Fankhauser
Researcher at University of Bern
Publications - 32
Citations - 896
Niklaus Fankhauser is an academic researcher from University of Bern. The author has contributed to research in topics: Cancer & Retrospective cohort study. The author has an hindex of 11, co-authored 32 publications receiving 738 citations. Previous affiliations of Niklaus Fankhauser include École Polytechnique Fédérale de Lausanne & ETH Zurich.
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Identification of GPI anchor attachment signals by a Kohonen self-organizing map
Niklaus Fankhauser,Pascal Mäser +1 more
TL;DR: In order to identify anchoring signals in silico, neural networks are trained on known GPI-anchored proteins, systematically optimizing input parameters, and a Kohonen self-organizing map,GPI-SOM, was developed that predicts G PI-anchoring proteins with high accuracy.
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HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease
Peter Mirtschink,Jaya Krishnan,Jaya Krishnan,Fiona Grimm,Fiona Grimm,Alexandre Sarre,Manuel Hörl,Melis Kayikci,Niklaus Fankhauser,Yann Christinat,Cédric Cortijo,Owen Feehan,Ana Vukolic,Samuel Sossalla,Sebastian Stehr,Jernej Ule,Jernej Ule,Nicola Zamboni,Thierry Pedrazzini,Wilhelm Krek +19 more
TL;DR: Heart-specific depletion of SF3B1 or genetic ablation of Khk, but not Khk-A alone, in mice, suppresses pathological stress-induced fructose metabolism, growth and contractile dysfunction, thus defining signalling components and molecular underpinnings of a fructose metabolism regulatory system crucial for pathological growth.
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p53 suppresses type II endometrial carcinomas in mice and governs endometrial tumour aggressiveness in humans
Peter J. Wild,Kristian Ikenberg,Thomas J. Fuchs,Markus Rechsteiner,Strahil Georgiev,Niklaus Fankhauser,Aurelia Noske,Matthias Roessle,Rosmarie Caduff,Athanassios Dellas,Daniel Fink,Holger Moch,Wilhelm Krek,Ian J. Frew +13 more
TL;DR: It is suggested that molecular alterations in p53 and the mTORC1 pathway play different roles in the initiation of the different endometrial cancer subtypes, but that combined p53 inactivation and mTORc1 pathway activation are unifying pathogenic features among histologically diverse subtypes of late stage aggressive endometricrial tumours.
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Novel prognostic markers in the serum of patients with castration-resistant prostate cancer derived from quantitative analysis of the pten conditional knockout mouse proteome.
Martin Kälin,Martin Kälin,Igor Cima,Ralph Schiess,Niklaus Fankhauser,Thomas Powles,Peter J. Wild,Peter J. Wild,Arnoud J. Templeton,Thomas Cerny,Ruedi Aebersold,Ruedi Aebersold,Wilhelm Krek,Silke Gillessen +13 more
TL;DR: Analysis of the serum proteome in mCRPC patients based on the Pten conditional knockout model, combined with known prognostic factors, potentially improves accuracy of prognostic nomograms.
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miR-28-5p Promotes Chromosomal Instability in VHL-Associated Cancers by Inhibiting Mad2 Translation
Michael Hell,Claudio R. Thoma,Niklaus Fankhauser,Yann Christinat,Thomas C. Weber,Wilhelm Krek +5 more
TL;DR: In this article, the authors identify a regulatory mechanism for Mad2 expression involving miR-28-5p-mediated inhibition of Mad2 translation and demonstrate that this mechanism is triggered by inactivation of the tumor suppressor VHL, the most common event in clear cell renal cell carcinoma (ccRCC).